Proteins/UNIPROT:Q9NUQ9

CYRIB

ProteinUNIPROT:Q9NUQ9

Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling. Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization. Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry. Also restricts infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress..

Function from UniProtKB (Q9NUQ9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

23 statements

23 statements · 3 reference databases · Subject: CYRIB · Sources: gene ontology, Hetionet, Reactome

Order

CYRIB covaries with GRIN2DProteinHetionet hetionet:covaries:2906-51571Inferred only
HOXC12 covaries with CYRIBProteinHetionet hetionet:covaries:3228-51571Inferred only
CYRIB covaries with RPL13ProteinHetionet hetionet:covaries:51571-6137Inferred only
ZBTB7B covaries with CYRIBProteinHetionet hetionet:covaries:51043-51571Inferred only
IKBKE interacts with CYRIBProteinHetionet hetionet:interacts:51571-9641Inferred only
MAPK6 interacts with CYRIBProteinHetionet hetionet:interacts:51571-5597Inferred only
UBC interacts with CYRIBProteinHetionet hetionet:interacts:51571-7316Inferred only
CYRIB participates in HemostasisPathwayReactome R-HSA-109582Inferred only
CYRIB participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
CYRIB participates in Platelet degranulationPathwayReactome R-HSA-114608Inferred only
CYRIB participates in Response to elevated platelet cytosolic Ca2+PathwayReactome R-HSA-76005Inferred only
CYRIB regulates negative regulation of actin filament polymerizationBiological processgene ontology Q9NUQ9|GO:0030837Inferred only

Show the remaining 11

CYRIB regulates negative regulation of small GTPase mediated signal transductionBiological processgene ontology Q9NUQ9|GO:0051058Inferred only
CYRIB regulates positive regulation of memory T cell activationBiological processgene ontology Q9NUQ9|GO:2000568Inferred only
CYRIB regulates positive regulation of T cell activationBiological processgene ontology Q9NUQ9|GO:0050870Inferred only
CYRIB regulates positive regulation of T cell mediated cytotoxicityBiological processgene ontology Q9NUQ9|GO:0001916Inferred only
CYRIB regulates positive regulation of type II interferon productionBiological processgene ontology Q9NUQ9|GO:0032729Inferred only
CYRIB regulates regulation of cell migrationBiological processgene ontology Q9NUQ9|GO:0030334Inferred only
CYRIB regulates regulation of chemotaxisBiological processgene ontology Q9NUQ9|GO:0050920Inferred only
CYRIB regulates regulation of establishment of cell polarityBiological processgene ontology Q9NUQ9|GO:2000114Inferred only
CYRIB regulates regulation of mitochondrial fissionBiological processgene ontology Q9NUQ9|GO:0090140Inferred only
FAT1 decreases the expression of CYRIBProteinHetionet hetionet:regulates:2195-51571Inferred only
RFX5 increases the expression of CYRIBProteinHetionet hetionet:regulates:5993-51571Inferred only

Other names

4 names

Resolves to: CYRIB

Also called: CYFIP-related Rac1 interactor BCYRIFAM49BL1

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