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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q9BYN0

SRXN1

Protein·UNIPROT:Q9BYN0

Open in the graph

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase..

Function from UniProtKB (Q9BYN0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

11 statements

11 statements · 4 reference databases · Subject: SRXN1 · Sources: Hetionet, Reactome, UniProt, WikiPathways

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SRXN1 covaries with TMEM200BProteinHetionet hetionet:covaries:140809-399474Inferred only
SRXN1 participates in Cellular response to chemical stressPathwayReactome R-HSA-9711123Inferred only
SRXN1 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
SRXN1 participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
SRXN1 participates in KEAP1-NFE2L2 pathwayPathwayReactome R-HSA-9755511Inferred only
SRXN1 participates in NFE2L2 regulating anti-oxidant/detoxification enzymesPathwayReactome R-HSA-9818027Inferred only
SRXN1 participates in NRF2 pathwayPathwayWikiPathways WP2884Inferred only
SRXN1 participates in Nuclear events mediated by NFE2L2PathwayReactome R-HSA-9759194Inferred only
SRXN1 participates in Nuclear receptors meta pathwayPathwayWikiPathways WP2882Inferred only
SRXN1 participates in Photodynamic therapy induced NFE2L2 NRF2 survival signalingPathwayWikiPathways WP3612Inferred only
SRXN1 requires the cofactor magnesium(2+)CompoundUniProt Q9BYN0Inferred only

Reactions

1 reaction

S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin]+[protein]-dithiol+ATP(4-)S-hydroxy-L-cysteinyl-[peroxiredoxin]+[protein]-disulfide+ADP(3-)+hydrogenphosphate
Catalysed by SRXN1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:17545CC BY 4.0Reference data

Other names

4 names

Resolves to: SRXN1

Also called: C20orf139SRXSRX1Sulfiredoxin-1

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