3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA

Three steps

• 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Beta Oxidation of Fatty Acid
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, ACADM, ACADS, LPCAT4mitochondrial matrix

• undecanoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 8 morecytosolOne of 3 routes

• cholesteryl (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. fatty-acyl-CoA elongation (N-C18:3CoA)
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by ACAA1, ELOVL4, ELOVL6, ELOVL2 and 3 morecytosol, endoplasmic reticulum

• (5Z)-tetradecenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 9 routes

• (3E)-decenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 6 morecytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrix

• an N(2)-acyl-L-glutamineReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by ACAA1, GLYATL1B, GLYATL1cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 9 routes

• tricosanoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 5 routes

• a 3-oxoacyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by ACAA1, SCP2, ACAA2, HADHBcytosol