2-deoxy-D-ribose 5-phosphate

Three steps

• N-acetylputrescineReach from here →
  1. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
  2. Acetaldehyde:NAD+ oxidoreductase
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by DERA, ALDH3A1, ALDH3B1, ALDH1A3 and 2 morecytosol

• (2R)-2-phosphoglycerateReach from here →
  1. 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate
  2. 2-deoxy-alpha-D-ribose 1-phosphate + (2R)-3-phospho-glyceroyl phosphate = 2-deoxy-alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
  3. D-phosphoglycerate 2,3-phosphomutase

  Catalysed by PGM2, PGM2L1, BPGM, PGAM2 and 2 morecytosolOne of 2 routes

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
  2. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  3. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA

  Catalysed by DERA, TPI1, GNPAT

• alpha-D-glucose 1,6-bisphosphateReach from here →
  1. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
  2. D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)
  3. 3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase

  Catalysed by DERA, GAPDHS, GAPDH, PGM2L1cytosolOne of 3 routes

• N(8)-acetylspermidineReach from here →
  1. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
  2. Acetaldehyde:NAD+ oxidoreductase
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by DERA, ALDH3A1, ALDH3B1, ALDH1A3 and 2 morecytosol

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
  2. Acetaldehyde:NAD+ oxidoreductase
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by DERA, ALDH3A1, ALDH3B1, ALDH1A3 and 2 morecytosol

• dIMPReach from here →
  1. 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate
  2. 2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
  3. dIMP + inosine = 2'-deoxyinosine + IMP

  Catalysed by PGM2, PNP, NT5C2

• alpha-D-ribose 1,5-bisphosphateReach from here →
  1. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
  2. D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)
  3. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)

  Catalysed by DERA, GAPDHS, GAPDH, PGM2L1