O-octanoyl-(R)-carnitine

Three steps

• pristanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. fatty-acid-CoA ligase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosolOne of 2 routes

• undecanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 6 moremitochondrial matrix, cytosolOne of 3 routes

• N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate

  Catalysed by SLC25A20, ASAH1, ACER2, ACER1 and 2 moremitochondrial matrix, cytosol, endoplasmic reticulum

• 18-hydroxy-(9Z)-octadecenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (9Z)-octadecenoate + reduced [NADPH--hemoprotein reductase] + O2 = 18-hydroxy-(9Z)-octadecenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC25A20, CYP4A11, CYP4F11mitochondrial matrix, cytosol, endoplasmic reticulum

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = sn-glycero-3-phospho-1D-myo-inositol + (9Z)-octadecenoate + H(+)

  Catalysed by SLC25A20, ABHD12mitochondrial matrix, cytosol, endoplasmic reticulum

• (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O

  Catalysed by SLC25A20, PTGS2mitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by SLC25A20, PTGS2mitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by SLC25A20, PTGS2mitochondrial matrix, cytosol, endoplasmic reticulum

• 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. Arachidonate: oxygen 11-oxidoreductase

  Catalysed by SLC25A20, ALOX12mitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• prostaglandin G2Reach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. Arachidonate:oxygen oxidoreductase

  Catalysed by SLC25A20, PTGS1, PTGS2mitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by SLC25A20, SLC22A8, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC25A20, CYP2C9mitochondrial matrix, cytosol, endoplasmic reticulum

• 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by SLC25A20, CYP1A1, CYP1A2, CYP2E1 and 24 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 4 routes

• 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by SLC25A20, CYP1A1, CYP1A2, CYP2E1 and 23 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 3 routes

• 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserineReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoserine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by SLC25A20, ABHD16Amitochondrial matrix, cytosol, endoplasmic reticulum

• 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by SLC25A20, ABHD16Amitochondrial matrix, cytosol, endoplasmic reticulum

• 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by SLC25A20, ABHD16Amitochondrial matrix, cytosol, endoplasmic reticulum

• (5Z)-tetradecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 4 moremitochondrial matrix, cytosol

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 4 routes

• (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC25A20, CYP4F8mitochondrial matrix, cytosol, endoplasmic reticulum

• 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by SLC25A20, ALOX15Bmitochondrial matrix, cytosol, endoplasmic reticulum

• 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by SLC25A20, ALOX15Bmitochondrial matrix, cytosol, endoplasmic reticulum