(S)-carnitine

Three steps

• 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosolOne of 2 routes

• 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA

  Catalysed by CPT2, CPT1A, CPT1B, DGAT1 and 2 moreperoxisome

• hexadecyl hexadecanoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  3. hexadecan-1-ol + hexadecanoyl-CoA = hexadecyl hexadecanoate + CoA

  Catalysed by CPT2, CPT1A, CPT1B, DGAT1 and 2 moreperoxisome

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  3. 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CPT2, CPT1A, CPT1B, MOGAT2 and 1 moreperoxisomeOne of 2 routes

• 2-hydroxyhexadecyl hexadecanoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  3. hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA

  Catalysed by CPT2, CPT1A, CPT1B, DGAT1 and 1 moreperoxisome

• 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosolOne of 2 routes

• 1,2-O,O-dihexadecanoyl-1,2-hexadecanediolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  3. hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA

  Catalysed by CPT2, CPT1A, CPT1B, DGAT1peroxisome

• 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Utilized Transport
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreendoplasmic reticulum, cytosol

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Utilized Transport
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 2-(9Z-octadecenoyl)-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 9 moreendoplasmic reticulum, cytosolOne of 2 routes

• 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 2-(9Z-octadecenoyl)-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosolOne of 2 routes

• decyl (9Z)-octadecenoateReach from here →
  1. Utilized Transport
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. decan-1-ol + (9Z)-octadecenoyl-CoA = decyl (9Z)-octadecenoate + CoA

  Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 5 moreendoplasmic reticulum, cytosol

• hexadecyl (9Z)-octadecenoateReach from here →
  1. Utilized Transport
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. hexadecan-1-ol + (9Z)-octadecenoyl-CoA = hexadecyl (9Z)-octadecenoate + CoA

  Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreendoplasmic reticulum, cytosol

• 1-O-(9Z)-hexadecenyl (9Z)-octadecenoateReach from here →
  1. Utilized Transport
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. (9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA

  Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreendoplasmic reticulum, cytosol

• octadecyl (9Z)-octadecenoateReach from here →
  1. Utilized Transport
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. octadecan-1-ol + (9Z)-octadecenoyl-CoA = octadecyl (9Z)-octadecenoate + CoA

  Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreendoplasmic reticulum, cytosol

• 1-O-(9Z)-octadecenyl (9Z)-octadecenoateReach from here →
  1. Utilized Transport
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. (9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA

  Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreendoplasmic reticulum, cytosol

• eicosan-1-olReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 2 NADPH + 2 H(+) = eicosan-1-ol + 2 NADP(+) + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosol

• 1-O-eicosanyl (9Z)-octadecenoateReach from here →
  1. Utilized Transport
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. eicosan-1-ol + (9Z)-octadecenoyl-CoA = 1-O-eicosanyl (9Z)-octadecenoate + CoA

  Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 5 moreendoplasmic reticulum, cytosol

• hexadecyl (9Z)-hexadecenoateReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. hexadecan-1-ol + (9Z)-hexadecenoyl-CoA = hexadecyl (9Z)-hexadecenoate + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosol

• hexadecyl octadecanoateReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. hexadecan-1-ol + octadecanoyl-CoA = hexadecyl octadecanoate + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol

• 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA

  Catalysed by CPT2, CPT1A, CPT1B, MOGAT3peroxisome

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerolReach from here →
  1. Utilized Transport
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA

  Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 5 moreendoplasmic reticulum, cytosol

• 1,3-di-(9Z-octadecenoyl)-glycerolReach from here →
  1. Utilized Transport
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. 1-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,3-di-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreendoplasmic reticulum, cytosolOne of 2 routes

• 2,3-di-(9Z)-octadecenoyl-sn-glycerolReach from here →
  1. Utilized Transport
  2. 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
  3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoate + H(+)

  Catalysed by DGAT1, LIPA, PNPLA4, LIPE and 2 moreendoplasmic reticulum, cytosolOne of 2 routes

• 1-(9Z-octadecenoyl)-3-hexadecanoylglycerolReach from here →
  1. Utilized Transport
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. 1-hexadecanoylglycerol + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-3-hexadecanoylglycerol + CoA

  Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreendoplasmic reticulum, cytosol

• di-(9Z)-octadecenoylglycerolReach from here →
  1. Utilized Transport
  2. 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
  3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)

  Catalysed by DGAT1, LIPA, PNPLA4, LIPE and 9 moreendoplasmic reticulum, cytosolOne of 2 routes

• 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, CROT and 1 morecytosol, mitochondrial matrix

• 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, CROT and 1 morecytosol, mitochondrial matrix

• 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by CPT2, CPT1A, CPT1B, LCLAT1peroxisome

• 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. Utilized Transport
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 moreendoplasmic reticulum, cytosol

• 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. Utilized Transport
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 moreendoplasmic reticulum, cytosol

• 1-O-hexadecyl-3-(9Z)-octadecenoylglycerolReach from here →
  1. Utilized Transport
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. 1-O-hexadecylglycerol + (9Z)-octadecenoyl-CoA = 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol + CoA

  Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 5 moreendoplasmic reticulum, cytosol

• 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoateReach from here →
  1. Utilized Transport
  2. fatty acylamide amidohydrolase
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by FAAH, PLA2G15endoplasmic reticulum, cytosol

• (9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. Utilized Transport
  2. fatty acylamide amidohydrolase
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by FAAH, PLA2G15endoplasmic reticulum, cytosol

• 1-O-alkyl-3-acylglycerolReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 5 morecytosol, Golgi apparatus

• hexadecanedioateReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. Production of Hexadecanedioylcarnitine
  3. hexadecanedioyl-CoA + H2O = hexadecanedioate + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, ABCD3cytosolOne of 2 routes

• (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
  3. ELOVL fatty acid elongase (trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol, endoplasmic reticulumOne of 2 routes

• 3-oxo-(11Z)-octadecenoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosol

• 3-oxo-(13Z)-eicosenoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
  3. (11Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, ELOVL5cytosol

• 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Utilized Transport
  2. arachidonic acid:oxygen 1-oxidoreductase
  3. 10-HETE[n] + NAD+[n] = H+[n] + NADH[n] + 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate[n]

  Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 24 moreendoplasmic reticulum, cytosol, nucleusOne of 3 routes

• 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosolOne of 2 routes

• 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. Utilized Transport
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 moreendoplasmic reticulum, cytosol

• 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphateReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol

• 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerolReach from here →
  1. Utilized Transport
  2. Fas180
  3. 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)

  Catalysed by ABHD11endoplasmic reticulum, cytosol

• 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. 1-octadecanoyl-sn-glycero-3-phosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol

• (11Z,14Z)-eicosadienoateReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
  3. (11Z,14Z)-eicosadienoyl-CoA hydrolase

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 10 morecytosolOne of 13 routes

• (17Z)-hexacosenoateReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (ximenic acid)
  3. Hexacosenoyl-CoA hydrolase

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosolOne of 13 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (DPA)
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosolOne of 13 routes

• (7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)
  3. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosolOne of 14 routes

• 2,6,10,14-tetramethylpentadecanoateReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. fatty-acid-CoA ligase
  3. peroxisomal acyl-CoA thioesterase

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 1 morecytosol, peroxisomeOne of 2 routes