Proteins/UNIPROT:Q6KCM7

SLC25A25

ProteinUNIPROT:Q6KCM7Mitochondrial adenyl nucleotide antiporter SLC25A251 compound

Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane (By similarity). Has calcium-dependent ATP-magnesium/inorganic phosphate antiporter activity. Could also have a broader specificity for adenyl nucleotides (By similarity). By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways (By similarity). Acts downstream of Ca(2+)-permeable cation channel PKD2/TRPP2 and it is likely that PKD2-mediated Ca(2+) signaling activates SLC25A25 antiporter activity (By similarity). Required for left-right pattern specification (By similarity)..

Function from UniProtKB (Q6KCM7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · transported by

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

magnesium(2+)ElementCHEBI:18420Inferred only3 paths3 endpoints

What the reference databases state

Statements

11 statements

11 statements · 4 reference databases · Subject: SLC25A25 · Sources: Bgee, Hetionet, Rhea, WikiPathways

Order

SLC25A25 covaries with HOXC13ProteinHetionet hetionet:covaries:114789-3229Inferred only
OR6C6 covaries with SLC25A25ProteinHetionet hetionet:covaries:114789-283365Inferred only
SLC25A25 covaries with SFT2D3ProteinHetionet hetionet:covaries:114789-84826Inferred only
SLC25A25 is expressed in gallbladderAnatomyBgee ENSG00000148339Inferred only
SLC25A25 is expressed in mucosa of stomachAnatomyBgee ENSG00000148339Inferred only
SLC25A25 is expressed in right lobe of liverAnatomyBgee ENSG00000148339Inferred only
UBC interacts with SLC25A25ProteinHetionet hetionet:interacts:114789-7316Inferred only
SLC25A25 participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
ATP(4-) is transported by SLC25A25CompoundRhea RHEA:65840Inferred only
hydrogenphosphate is transported by SLC25A25CompoundRhea RHEA:65840Inferred only
magnesium(2+) is transported by SLC25A25CompoundRhea RHEA:65840Inferred only

Reactions

1 reaction

magnesium(2+)+hydrogenphosphate+ATP(4-)magnesium(2+)+hydrogenphosphate+ATP(4-)
Transported by SLC25A25 or SLC25A24 or SLC25A41 or SLC25A23
Reaction pageDirection not assertedBalanced
Rhea RHEA:65840CC BY 4.0Reference data

Other names

9 names

Resolves to: SLC25A25

Also called: APC3KIAA1896MCSC3Mitochondrial ATP-Mg/Pi carrier protein 3Mitochondrial Ca(2+)-dependent solute carrier protein 3SCaMC-2SCAMC2Short calcium-binding mitochondrial carrier protein 2Solute carrier family 25 member 25

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