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Proteins/UNIPROT:Q8WXE1

ATRIP

Protein·UNIPROT:Q8WXE1

Open in the graph

Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein..

Function from UniProtKB (Q8WXE1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

breast cancer has a germline basis in ATRIPDiseaseGenCC HGNC:33499|MONDO:0007254Inferred only
Seckel syndrome has a germline basis in ATRIPDiseaseGenCC HGNC:33499|MONDO:0019342Inferred only

Statements

49 statements

49 statements · 4 reference databases · Subject: ATRIP · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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LRRC70 covaries with ATRIPProteinHetionet hetionet:covaries:100130733-84126Inferred only
NEUROD6 covaries with ATRIPProteinHetionet hetionet:covaries:63974-84126Inferred only
ATRIP covaries with SETD2ProteinHetionet hetionet:covaries:29072-84126Inferred only
ATRIP covaries with TAS2R9ProteinHetionet hetionet:covaries:50835-84126Inferred only
ATRIP covaries with TNFSF13BProteinHetionet hetionet:covaries:10673-84126Inferred only
ATM interacts with ATRIPProteinHetionet hetionet:interacts:472-84126Inferred only
ATR interacts with ATRIPProteinHetionet hetionet:interacts:545-84126Inferred only
CDC6 interacts with ATRIPProteinHetionet hetionet:interacts:84126-990Inferred only
CDK9 interacts with ATRIPProteinHetionet hetionet:interacts:1025-84126Inferred only
CEP164 interacts with ATRIPProteinHetionet hetionet:interacts:22897-84126Inferred only
CINP interacts with ATRIPProteinHetionet hetionet:interacts:51550-84126Inferred only
ATRIP interacts with IFT20ProteinHetionet hetionet:interacts:84126-90410Inferred only

Show the remaining 37

IKBKG interacts with ATRIPProteinHetionet hetionet:interacts:84126-8517Inferred only
PRKDC interacts with ATRIPProteinHetionet hetionet:interacts:5591-84126Inferred only
RPA1 interacts with ATRIPProteinHetionet hetionet:interacts:6117-84126Inferred only
RRM2B interacts with ATRIPProteinHetionet hetionet:interacts:50484-84126Inferred only
SUMO2 interacts with ATRIPProteinHetionet hetionet:interacts:6613-84126Inferred only
TOPBP1 interacts with ATRIPProteinHetionet hetionet:interacts:11073-84126Inferred only
ATRIP participates in Activation of ATR in response to replication stressPathwayReactome R-HSA-176187Inferred only
ATRIP participates in ATR signalingPathwayWikiPathways WP3875Inferred only
ATRIP participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
ATRIP participates in Cell Cycle CheckpointsPathwayReactome R-HSA-69620Inferred only
ATRIP participates in Defective homologous recombination repair (HRR) due to BRCA2 loss of functionPathwayReactome R-HSA-9701190Inferred only
ATRIP participates in DiseasePathwayReactome R-HSA-1643685Inferred only
ATRIP participates in Diseases of DNA Double-Strand Break RepairPathwayReactome R-HSA-9675136Inferred only
ATRIP participates in Diseases of DNA repairPathwayReactome R-HSA-9675135Inferred only
ATRIP participates in DNA damage responsePathwayWikiPathways WP707Inferred only
ATRIP participates in DNA Double-Strand Break RepairPathwayReactome R-HSA-5693532Inferred only
ATRIP participates in DNA IR damage and cellular response via ATRPathwayWikiPathways WP4016Inferred only
ATRIP participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
ATRIP participates in Fanconi Anemia PathwayPathwayReactome R-HSA-6783310Inferred only
ATRIP participates in G2/M CheckpointsPathwayReactome R-HSA-69481Inferred only
ATRIP participates in G2/M DNA damage checkpointPathwayReactome R-HSA-69473Inferred only
ATRIP participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
ATRIP participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
ATRIP participates in HDR through Homologous Recombination (HRR)PathwayReactome R-HSA-5685942Inferred only
ATRIP participates in HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)PathwayReactome R-HSA-5693567Inferred only
ATRIP participates in HDR through Single Strand Annealing (SSA)PathwayReactome R-HSA-5685938Inferred only
ATRIP participates in Homologous DNA Pairing and Strand ExchangePathwayReactome R-HSA-5693579Inferred only
ATRIP participates in Homology Directed RepairPathwayReactome R-HSA-5693538Inferred only
ATRIP participates in Impaired BRCA2 binding to RAD51PathwayReactome R-HSA-9709570Inferred only
ATRIP participates in miRNA regulation of DNA damage responsePathwayWikiPathways WP1530Inferred only
ATRIP participates in Presynaptic phase of homologous DNA pairing and strand exchangePathwayReactome R-HSA-5693616Inferred only
ATRIP participates in Processing of DNA double-strand break endsPathwayReactome R-HSA-5693607Inferred only
ATRIP participates in Regulation of TP53 ActivityPathwayReactome R-HSA-5633007Inferred only
ATRIP participates in Regulation of TP53 Activity through PhosphorylationPathwayReactome R-HSA-6804756Inferred only
ATRIP participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
ATRIP participates in Transcriptional Regulation by TP53PathwayReactome R-HSA-3700989Inferred only
ATRIP regulates regulation of double-strand break repairBiological processgene ontology Q8WXE1|GO:2000779Inferred only

Other names

3 names

Resolves to: ATRIP

Also called: AGS1ATM and Rad3-related-interacting proteinATR-interacting protein

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