Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:O75884

RBBP9

Protein·UNIPROT:O75884Serine hydrolase RBBP9

Open in the graph

Serine hydrolase (Probable). Catalyzes the hydrolytic activation of amino acid ester of the antiviral prodrug valacyclovir to its corresponding active drug, acyclovir. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1..

Function from UniProtKB (O75884), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

7 statements

7 statements · 2 reference databases · Subject: RBBP9 · Sources: Hetionet, Rhea

Search this listOrder

RB1 interacts with RBBP9ProteinHetionet hetionet:interacts:10741-5925Inferred only
RBL1 interacts with RBBP9ProteinHetionet hetionet:interacts:10741-5933Inferred only
RBL2 interacts with RBBP9ProteinHetionet hetionet:interacts:10741-5934Inferred only
RBBP9 interacts with TERF2IPProteinHetionet hetionet:interacts:10741-54386Inferred only
UBC interacts with RBBP9ProteinHetionet hetionet:interacts:10741-7316Inferred only
RBBP9 interacts with YRDCProteinHetionet hetionet:interacts:10741-79693Inferred only
valacyclovir is a substrate of RBBP9CompoundRhea RHEA:83871Inferred only

Reactions

1 reaction

valacyclovir+wateracyclovir+L-valine+hydron
Catalysed by RBBP9 or BPHL
Reaction pageLeft to rightBalanced
Rhea RHEA:83871CC BY 4.0Reference data

Other names

8 names

Resolves to: RBBP9

Also called: B5T-overexpressed gene proteinBOGProtein BOGRBBP-10RBBP-9RBBP10Retinoblastoma-binding protein 10Retinoblastoma-binding protein 9

← Every protein Find it in the graph →