Proteins/UNIPROT:Q9Y5X4

NR2E3

ProteinUNIPROT:Q9Y5X4

Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression..

Function from UniProtKB (Q9Y5X4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

5 rows

enhanced S-cone syndrome has a germline basis in NR2E3DiseaseGenCC HGNC:7974|MONDO:0100288Inferred only
Goldmann-Favre syndrome has a germline basis in NR2E3DiseaseGenCC HGNC:7974|MONDO:0100289Inferred only
inherited retinal dystrophy has a germline basis in NR2E3DiseaseGenCC HGNC:7974|MONDO:0019118Inferred only
retinitis pigmentosa has a germline basis in NR2E3DiseaseGenCC HGNC:7974|MONDO:0019200Inferred only
retinitis pigmentosa 37 has a germline basis in NR2E3DiseaseGenCC HGNC:7974|MONDO:0012625Inferred only

Statements

25 statements

25 statements · 2 reference databases · Subject: NR2E3 · Sources: gene ontology, Hetionet

Order

CDK9 interacts with NR2E3ProteinHetionet hetionet:interacts:10002-1025Inferred only
CRX interacts with NR2E3ProteinHetionet hetionet:interacts:10002-1406Inferred only
NR2E3 interacts with DEDD2ProteinHetionet hetionet:interacts:10002-162989Inferred only
NR2E3 interacts with DHX30ProteinHetionet hetionet:interacts:10002-22907Inferred only
ELAVL2 interacts with NR2E3ProteinHetionet hetionet:interacts:10002-1993Inferred only
HDAC1 interacts with NR2E3ProteinHetionet hetionet:interacts:10002-3065Inferred only
HDAC3 interacts with NR2E3ProteinHetionet hetionet:interacts:10002-8841Inferred only
HOXC13 interacts with NR2E3ProteinHetionet hetionet:interacts:10002-3229Inferred only
NR2E3 interacts with IRF9ProteinHetionet hetionet:interacts:10002-10379Inferred only
NR2E3 interacts with MYBBP1AProteinHetionet hetionet:interacts:10002-10514Inferred only
NCOR1 interacts with NR2E3ProteinHetionet hetionet:interacts:10002-9611Inferred only
NR1D1 interacts with NR2E3ProteinHetionet hetionet:interacts:10002-9572Inferred only

Show the remaining 13

NR3C1 interacts with NR2E3ProteinHetionet hetionet:interacts:10002-2908Inferred only
POLR3D interacts with NR2E3ProteinHetionet hetionet:interacts:10002-661Inferred only
RARA interacts with NR2E3ProteinHetionet hetionet:interacts:10002-5914Inferred only
RBBP4 interacts with NR2E3ProteinHetionet hetionet:interacts:10002-5928Inferred only
NR2E3 interacts with RBFOX2ProteinHetionet hetionet:interacts:10002-23543Inferred only
RBL1 interacts with NR2E3ProteinHetionet hetionet:interacts:10002-5933Inferred only
RXRA interacts with NR2E3ProteinHetionet hetionet:interacts:10002-6256Inferred only
RXRB interacts with NR2E3ProteinHetionet hetionet:interacts:10002-6257Inferred only
NR2E3 interacts with SIN3AProteinHetionet hetionet:interacts:10002-25942Inferred only
SNAPC1 interacts with NR2E3ProteinHetionet hetionet:interacts:10002-6617Inferred only
NR2E3 interacts with TBL3ProteinHetionet hetionet:interacts:10002-10607Inferred only
ZNF232 interacts with NR2E3ProteinHetionet hetionet:interacts:10002-7775Inferred only
NR2E3 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9Y5X4|GO:0045944Inferred only

Other names

4 names

Resolves to: NR2E3

Also called: Nuclear receptor subfamily 2 group E member 3PNRRetina-specific nuclear receptorRNR

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