Proteins/UNIPROT:Q92994

BRF1

ProteinUNIPROT:Q92994

General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.

Function from UniProtKB (Q92994), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

cerebellar-facial-dental syndrome has a germline basis in BRF1DiseaseGenCC HGNC:11551|MONDO:0014529Inferred only

Statements

26 statements

26 statements · 3 reference databases · Subject: BRF1 · Sources: Hetionet, Reactome, WikiPathways

Order

BRF1 covaries with CDCA4ProteinHetionet hetionet:covaries:2972-55038Inferred only
FGFR3 covaries with BRF1ProteinHetionet hetionet:covaries:2261-2972Inferred only
GPR143 covaries with BRF1ProteinHetionet hetionet:covaries:2972-4935Inferred only
HTRA3 covaries with BRF1ProteinHetionet hetionet:covaries:2972-94031Inferred only
LONRF2 covaries with BRF1ProteinHetionet hetionet:covaries:164832-2972Inferred only
TACC3 covaries with BRF1ProteinHetionet hetionet:covaries:10460-2972Inferred only
APP interacts with BRF1ProteinHetionet hetionet:interacts:2972-351Inferred only
CSNK2A1 interacts with BRF1ProteinHetionet hetionet:interacts:1457-2972Inferred only
CSNK2A2 interacts with BRF1ProteinHetionet hetionet:interacts:1459-2972Inferred only
BRF1 interacts with DTNBP1ProteinHetionet hetionet:interacts:2972-84062Inferred only
BRF1 interacts with GTF3C5ProteinHetionet hetionet:interacts:2972-9328Inferred only
BRF1 interacts with PCBD2ProteinHetionet hetionet:interacts:2972-84105Inferred only

Show the remaining 14

BRF1 interacts with RB1ProteinHetionet hetionet:interacts:2972-5925Inferred only
BRF1 interacts with RBL1ProteinHetionet hetionet:interacts:2972-5933Inferred only
BRF1 interacts with RBL2ProteinHetionet hetionet:interacts:2972-5934Inferred only
BRF1 interacts with SUMO2ProteinHetionet hetionet:interacts:2972-6613Inferred only
BRF1 interacts with TBPProteinHetionet hetionet:interacts:2972-6908Inferred only
BRF1 interacts with TP53ProteinHetionet hetionet:interacts:2972-7157Inferred only
BRF1 interacts with UBCProteinHetionet hetionet:interacts:2972-7316Inferred only
BRF1 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
BRF1 participates in RNA Polymerase III Abortive And Retractive InitiationPathwayReactome R-HSA-749476Inferred only
BRF1 participates in RNA Polymerase III TranscriptionPathwayReactome R-HSA-74158Inferred only
BRF1 participates in RNA Polymerase III Transcription InitiationPathwayReactome R-HSA-76046Inferred only
BRF1 participates in RNA Polymerase III Transcription Initiation From Type 1 PromoterPathwayReactome R-HSA-76061Inferred only
BRF1 participates in RNA Polymerase III Transcription Initiation From Type 2 PromoterPathwayReactome R-HSA-76066Inferred only
BRF1 participates in TAR syndromePathwayWikiPathways WP5362Inferred only

Other names

10 names

Resolves to: BRF1

Also called: B-related factor 1BRFBRF-1GTF3BhBRFhTFIIIB90TAF3B2TAF3CTATA box-binding protein-associated factor, RNA polymerase III, subunit 2TFIIIB90

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