Proteins/UNIPROT:Q6P2H8

TMEM53

ProteinUNIPROT:Q6P2H8

Ensures normal bone formation, through the negative regulation of bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD1/5/9 proteins..

Function from UniProtKB (Q6P2H8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

craniotubular dysplasia, Ikegawa type has a germline basis in TMEM53DiseaseGenCC HGNC:26186|MONDO:0859226Inferred only
skeletal dysplasia has a germline basis in TMEM53DiseaseGenCC HGNC:26186|MONDO:0018230Inferred only

Statements

9 statements

9 statements · 2 reference databases · Subject: TMEM53 · Sources: gene ontology, Hetionet

Order

H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 covaries with TMEM53ProteinHetionet hetionet:covaries:79639-8339Inferred only
NICOL1 covaries with TMEM53ProteinHetionet hetionet:covaries:401115-79639Inferred only
POMGNT1 covaries with TMEM53ProteinHetionet hetionet:covaries:55624-79639Inferred only
TRIM44 covaries with TMEM53ProteinHetionet hetionet:covaries:54765-79639Inferred only
APP interacts with TMEM53ProteinHetionet hetionet:interacts:351-79639Inferred only
TMEM53 regulates negative regulation of BMP signaling pathwayBiological processgene ontology Q6P2H8|GO:0030514Inferred only
TMEM53 regulates negative regulation of ossificationBiological processgene ontology Q6P2H8|GO:0030279Inferred only
TMEM53 regulates negative regulation of osteoblast differentiationBiological processgene ontology Q6P2H8|GO:0045668Inferred only
TMEM53 regulates regulation of nucleocytoplasmic transportBiological processgene ontology Q6P2H8|GO:0046822Inferred only

Other names

3 names

Resolves to: TMEM53

Also called: NET4Nuclear envelope transmembrane protein 4Transmembrane protein 53

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