Proteins/UNIPROT:Q8NAX2

KDF1

ProteinUNIPROT:Q8NAX2

Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity)..

Function from UniProtKB (Q8NAX2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

autosomal dominant hypohidrotic ectodermal dysplasia has a germline basis in KDF1DiseaseGenCC HGNC:26624|MONDO:0015884Inferred only
ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type has a germline basis in KDF1DiseaseGenCC HGNC:26624|MONDO:0015024Inferred only

Statements

28 statements

28 statements · 2 reference databases · Subject: KDF1 · Sources: gene ontology, Hetionet

Order

ARHGAP33 covaries with KDF1ProteinHetionet hetionet:covaries:115703-126695Inferred only
B3GALNT1 covaries with KDF1ProteinHetionet hetionet:covaries:126695-8706Inferred only
DDX21 covaries with KDF1ProteinHetionet hetionet:covaries:126695-9188Inferred only
DOK1 covaries with KDF1ProteinHetionet hetionet:covaries:126695-1796Inferred only
FBXL6 covaries with KDF1ProteinHetionet hetionet:covaries:126695-26233Inferred only
GAL3ST3 covaries with KDF1ProteinHetionet hetionet:covaries:126695-89792Inferred only
GFOD2 covaries with KDF1ProteinHetionet hetionet:covaries:126695-81577Inferred only
IKZF4 covaries with KDF1ProteinHetionet hetionet:covaries:126695-64375Inferred only
IRS4 covaries with KDF1ProteinHetionet hetionet:covaries:126695-8471Inferred only
KDM5C covaries with KDF1ProteinHetionet hetionet:covaries:126695-8242Inferred only
NPHS1 covaries with KDF1ProteinHetionet hetionet:covaries:126695-4868Inferred only
NSMCE2 covaries with KDF1ProteinHetionet hetionet:covaries:126695-286053Inferred only

Show the remaining 16

OR2V2 covaries with KDF1ProteinHetionet hetionet:covaries:126695-285659Inferred only
PKIA covaries with KDF1ProteinHetionet hetionet:covaries:126695-5569Inferred only
POMGNT1 covaries with KDF1ProteinHetionet hetionet:covaries:126695-55624Inferred only
RBM14 covaries with KDF1ProteinHetionet hetionet:covaries:10432-126695Inferred only
RBM3 covaries with KDF1ProteinHetionet hetionet:covaries:126695-5935Inferred only
RTN4R covaries with KDF1ProteinHetionet hetionet:covaries:126695-65078Inferred only
SAV1 covaries with KDF1ProteinHetionet hetionet:covaries:126695-60485Inferred only
SENP2 covaries with KDF1ProteinHetionet hetionet:covaries:126695-59343Inferred only
SMC6 covaries with KDF1ProteinHetionet hetionet:covaries:126695-79677Inferred only
SPECC1L covaries with KDF1ProteinHetionet hetionet:covaries:126695-23384Inferred only
SPRED3 covaries with KDF1ProteinHetionet hetionet:covaries:126695-399473Inferred only
TBX21 covaries with KDF1ProteinHetionet hetionet:covaries:126695-30009Inferred only
ZNF354B covaries with KDF1ProteinHetionet hetionet:covaries:117608-126695Inferred only
KDF1 regulates negative regulation of stem cell proliferationBiological processgene ontology Q8NAX2|GO:2000647Inferred only
KDF1 regulates positive regulation of epidermal cell differentiationBiological processgene ontology Q8NAX2|GO:0045606Inferred only
KDF1 regulates regulation of epidermal cell divisionBiological processgene ontology Q8NAX2|GO:0010482Inferred only

Other names

2 names

Resolves to: KDF1

Also called: C1orf172Keratinocyte differentiation factor 1

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