Pathway

PI5P Regulates TP53 Acetylation

Under conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase and, through interaction with ING2, result in nuclear retention/accumulation of ING2. ING2 binds TP53 (p53) and recruits histone acetyltransferase EP300 (p300) to TP53, leading to TP53 acetylation. Increased nuclear PI5P levels positively regulate TP53 acetylation.

Summary from Reactome (R-HSA-6811555), read 2026-09-23.

REACT:R-HSA-6811555Reactome

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What the reference databases state

Statements

9 statements

9 statements · 1 reference database · Subject: PI5P Regulates TP53 Acetylation · Sources: Reactome

Order

EP300 participates in PI5P Regulates TP53 AcetylationProteinReactome R-HSA-6811555Inferred only
ING2 participates in PI5P Regulates TP53 AcetylationProteinReactome R-HSA-6811555Inferred only
MAP2K6 participates in PI5P Regulates TP53 AcetylationProteinReactome R-HSA-6811555Inferred only
PIN1 participates in PI5P Regulates TP53 AcetylationProteinReactome R-HSA-6811555Inferred only
PIP4K2A participates in PI5P Regulates TP53 AcetylationProteinReactome R-HSA-6811555Inferred only
PIP4K2B participates in PI5P Regulates TP53 AcetylationProteinReactome R-HSA-6811555Inferred only
PIP4K2C participates in PI5P Regulates TP53 AcetylationProteinReactome R-HSA-6811555Inferred only
PIP4P1 participates in PI5P Regulates TP53 AcetylationProteinReactome R-HSA-6811555Inferred only
TP53 participates in PI5P Regulates TP53 AcetylationProteinReactome R-HSA-6811555Inferred only