Pathway
Interconversion of polyamines
The reactions catalyzed by aminopropyl-transferases annotated above are generally irreversible. But spermine and spermidine can be recycled respectively into spermidine and putrescine. These events require the formation of N-acetylated intermediates, N1-acetylspermine and N1-acetylspermidine catalyzed by a cytosolic acetyl-CoA:spermidine/spermine N1-acetyl-tranferase (SSAT) enzyme.
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Subsequently, polyamine-oxidase (PAO), a FAD enzyme present in the peroxysomes, yields a polyamine with release of an aldehyde (3-acetamindopropanal) and H2O2.
In addition, SMOX, a FAD-dependent, polyamine oxidase (PAOh1/SMO) that can efficiently use spermine as a substrate and is involved in interconversion reactions.
What the reference databases state
Statements
2 statements
2 statements · 1 reference database · Subject: Interconversion of polyamines · Sources: Reactome
- PAOX participates in Interconversion of polyaminesProteinReactome R-HSA-351200Inferred only
- SAT1 participates in Interconversion of polyaminesProteinReactome R-HSA-351200Inferred only