Pathway
Regulation of ornithine decarboxylase (ODC)
Polyamines increase the production of antizyme (AZ). The carboxy-terminal half of antizyme interacts with ODC, generating an inactive AZ:ODC heterodimer complex. A carboxy-terminal domain of ODC is exposed only within the heterodimer, and is the target for subsequent degradation. A domain within the amino-terminal portion of antizyme provides a function needed for efficient degradation of ODC by the proteasome.
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The proteasome cycle starts with the processing of AZ:ODC, sequestering ODC and then degrading it to peptides but releasing AZ. AZ participates in additional rounds of binding and degradation. Antizyme-mediated inhibition and destruction of ODC reduces synthesis of polyamines. Additionally, antizyme also inhibits polyamine transport into the cell. Antizyme production is reduced, completing the regulatory circuit.
REACT:R-HSA-350562Reactome
What the reference databases state
Statements
38 statements
38 statements · 1 reference database · Subject: Regulation of ornithine decarboxylase (ODC) · Sources: Reactome
- ADRM1 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- AZIN1 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- NQO1 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- OAZ1 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- OAZ2 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- OAZ3 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- ODC1 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMA1 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMA2 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMA3 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMA4 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMA5 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
Show the remaining 26
- PSMA6 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMA7 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMB1 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMB2 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMB3 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMB4 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMB5 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMB6 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMB7 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMC1 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMC2 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMC3 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMC4 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMC5 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMC6 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMD1 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMD11 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMD12 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMD13 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMD14 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMD2 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMD3 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMD6 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMD7 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- PSMD8 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only
- SEM1 participates in Regulation of ornithine decarboxylase (ODC)ProteinReactome R-HSA-350562Inferred only