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Proteins/UNIPROT:P61009
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity)..
(Microbial infection) Plays an important role in virion production of flaviviruses such as West Nile virus, Japanese enchephalitis virus, Dengue virus type 2 and Yellow Fever virus..
Function from UniProtKB (P61009), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
36 statements
36 statements · 3 reference databases · Subject: SPCS3 · Sources: Hetionet, Reactome, WikiPathways
2 reactions
MAM00211c+waterprotein polypeptide chain+proton+N(6),N(6),N(6)-trimethyl-L-lysine
Catalysed by SPCS3 & SEC11A & SPCS2 & SEC11C & SPCS1
Reaction pageLeft to rightBalance undeterminableEC 3.4.21.89, 3.4.-.-cytosol
Human-GEM MAR06978CC BY 4.0Reference data
MAM00211r+waterprotein polypeptide chain+
4 names
Resolves to: SPCS3
Reaction pageLeft to rightBalance undeterminableEC 3.4.21.89, 3.4.-.-endoplasmic reticulum
Human-GEM MAR08029CC BY 4.0Reference data