Pathway
Deadenylation-dependent mRNA decay
After undergoing rounds of translation, mRNA is normally destroyed by the deadenylation-dependent pathway. Though the trigger is unclear, deadenylation likely proceeds in two steps: one catalyzed by the PAN2-PAN3 complex that shortens the poly(A) tail from about 200 adenosine residues to about 80 residues and one catalyzed by the CCR4-NOT complex or by the PARN enzyme that shortens the tail to about 10-15 residues.
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After deadenylation the mRNA is then hydrolyzed by either the 5' to 3' pathway or the 3' to 5' pathway. It is unknown what determinants target a mRNA to one pathway or the other.
The 5' to 3' pathway is initiated by binding of the Lsm1-7 complex to the 3' oligoadenylate tail followed by decapping by the DCP1-DCP2 complex. The 5' to 3' exoribonuclease XRN1 then hydrolyzes the remaining RNA.
The 3' to 5' pathway is initiated by the exosome complex at the 3' end of the mRNA. The exosome processively hydrolyzes the mRNA from 3' to 5', leaving only a capped oligoribonucleotide. The cap is then removed by the scavenging decapping enzyme DCPS.
REACT:R-HSA-429914Reactome
What the reference databases state
Statements
56 statements
56 statements · 1 reference database · Subject: Deadenylation-dependent mRNA decay · Sources: Reactome
- CNOT1 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- CNOT10 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- CNOT11 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- CNOT12 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- CNOT2 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- CNOT3 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- CNOT4 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- CNOT6 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- CNOT6L participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- CNOT7 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- CNOT8 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- CNOT9 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
Show the remaining 44
- DCP1A participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- DCP1B participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- DCP2 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- DCPS participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- DDX6 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- DIS3 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EDC3 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EDC4 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EIF4A1 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EIF4A2 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EIF4A3 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EIF4B participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EIF4E participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EIF4G1 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EXOSC1 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EXOSC2 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EXOSC3 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EXOSC4 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EXOSC5 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EXOSC6 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EXOSC7 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EXOSC8 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- EXOSC9 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- HBS1L participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- LSM1 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- LSM2 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- LSM3 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- LSM4 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- LSM5 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- LSM6 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- LSM7 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- NT5C3B participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- PABPC1 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- PAIP1 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- PAN2 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- PAN3 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- PARN participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- PATL1 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- SKIC2 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- SKIC3 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- SKIC8 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- TUT4 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- TUT7 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only
- XRN1 participates in Deadenylation-dependent mRNA decayProteinReactome R-HSA-429914Inferred only