Pathway
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Similar to the lipoxygenases, cytochrome P450 (CYP) enzymes catalyse the hydroxylation and epoxygenation of arachidonate. However, whereas lipoxygenases use an active non-heme iron to abstract hydrogen directly from arachidonate, CYPs contain a heme-iron active site that oxidizes its substrate by a different mechanism. They hydroxylate arachidonate between C-5 and C-15 to produce lipoxygenase-like hydroxyeicosatetraenoates (HETEs) and add a hydroxyl moiety to the sp3-hybridized omega-carbons to form a unique class of HETEs. The transfer of oxygen to the unstable arachidonate intermediate terminates the reaction by forming HETE or epoxy-eicosatrienoate (EETs), respectively.
What the reference databases state
Statements
9 statements
9 statements · 1 reference database · Subject: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) · Sources: Reactome
- CYP1A1 participates in Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)ProteinReactome R-HSA-2142816Inferred only
- CYP1A2 participates in Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)ProteinReactome R-HSA-2142816Inferred only
- CYP1B1 participates in Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)ProteinReactome R-HSA-2142816Inferred only
- CYP2C19 participates in Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)ProteinReactome R-HSA-2142816Inferred only
- CYP2C8 participates in Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)ProteinReactome R-HSA-2142816Inferred only
- CYP2C9 participates in Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)ProteinReactome R-HSA-2142816Inferred only
- CYP2U1 participates in Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)ProteinReactome R-HSA-2142816Inferred only
- CYP4A11 participates in Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)ProteinReactome R-HSA-2142816Inferred only
- CYP4F2 participates in Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)ProteinReactome R-HSA-2142816Inferred only