Regulation of PD-L1(CD274) Post-translational modification

Post-translational modification (PTM) of CD274 (PD-L1) is a crucial regulatory mechanism that significantly impacts its stability, surface presentation and interaction with its receptor PD-1, thus modulating normal immune function and immune response in cancers by influencing tumor immune evasion. PTMs of PD-L1 includes glycosylation, ubiquitination/de-ubiquitination, phosphorylation. These post-translational modifications collectively modulate the effectiveness of PD-L1 in immune checkpoint pathways and have significant implications for the development of immune therapies targeting PD-L1 in various diseases, including cancer. These processes reveal potential therapeutic targets for enhancing the efficacy of PD-L1 inhibitors by manipulating its post-translational regulation (Ming et al.,2021, Yamaguchi et al.,2022)

Summary from Reactome (R-HSA-9909615), read 2026-09-23.