Pathway
Phosphate bond hydrolysis by NUDT proteins
Enzymes that belong to the NUDT (Nudix) superfamily catalyze the hydrolysis of phosphodiester bonds in molecules including nucleoside triphosphates and diphosphates and nucleotide sugars. Family members are defined by the presence of an amino acid sequence motif shared with the E. coli MutT gene product, and are involved in diverse physiological processes.
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The hydrolysis of nucleoside di and triphosphates whose purine bases have been oxidized, deaminated, or methylated may protect the cell from the mutational damage that would occur if modified deoxyribonucleotides were incorporated into DNA and from the aberrant protein synthesis that would occur if modified ribonucleotides were incorporated into mRNA. The hydrolysis of ADP ribose may prevent the aberrant spontaneous ADP ribosylation of cellular proteins that could occur were this molecule to accumulate to high levels in the cell.
What the reference databases state
Statements
4 statements
4 statements · 1 reference database · Subject: Phosphate bond hydrolysis by NUDT proteins · Sources: Reactome
- ADPRM participates in Phosphate bond hydrolysis by NUDT proteinsProteinReactome R-HSA-2393930Inferred only
- NUDT15 participates in Phosphate bond hydrolysis by NUDT proteinsProteinReactome R-HSA-2393930Inferred only
- NUDT16 participates in Phosphate bond hydrolysis by NUDT proteinsProteinReactome R-HSA-2393930Inferred only
- NUDT5 participates in Phosphate bond hydrolysis by NUDT proteinsProteinReactome R-HSA-2393930Inferred only