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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q8TE99

PXYLP1

Protein·UNIPROT:Q8TE99

Open in the graph

Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains..

Function from UniProtKB (Q8TE99), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

1 statement

1 statement · 1 reference database · Subject: PXYLP1 · Sources: Hetionet

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UBC interacts with PXYLP1ProteinHetionet hetionet:interacts:7316-92370Inferred only

Reactions

3 reactions

water+NADP(3-)NAD(+)+phosphate(3-)
Catalysed by ACP3 or ACP5 or ACP4 or PXYLP1 or ACP7
Reaction pageLeft to rightBalancedEC 3.1.3.2GO:0005829
Human-GEM MAR04270CC BY 4.0Reference data
MAM01020e+waterphosphate(3-)+4-nitrophenol
Catalysed by

Other names

6 names

Resolves to: PXYLP1

Also called: Acid phosphatase-like protein 2ACPL2epididymis luminal protein 124HEL124Xylosyl phosphataseXYLP

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or ACP5

or ACP2

or ACP4

or ALPL

or ACP6

or ALPP

or ALPG

or ALPI

Reaction pageLeft to rightBalancedEC 3.1.3.1, 3.1.3.2, 3.1.3.41GO:0005615

Human-GEM MAR09569CC BY 4.0Reference data

3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein]+water3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]+hydrogenphosphate

Catalysed by PXYLP1

Reaction pageDirection not assertedBalance undeterminable

Rhea RHEA:56512CC BY 4.0Reference data