Proteins/UNIPROT:Q15572

TAF1C

ProteinUNIPROT:Q15572

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3..

Function from UniProtKB (Q15572), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

neurodevelopmental disorder has a germline basis in TAF1CDiseaseGenCC HGNC:11534|MONDO:0700092Inferred only

Statements

27 statements

27 statements · 4 reference databases · Subject: TAF1C · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

FLT3LG covaries with TAF1CProteinHetionet hetionet:covaries:2323-9013Inferred only
TAF1C covaries with GDF3ProteinHetionet hetionet:covaries:9013-9573Inferred only
TAF1C covaries with IL21RProteinHetionet hetionet:covaries:50615-9013Inferred only
TAF1C covaries with RP1L1ProteinHetionet hetionet:covaries:9013-94137Inferred only
TCOF1 covaries with TAF1CProteinHetionet hetionet:covaries:6949-9013Inferred only
TAF1C covaries with TMEM69ProteinHetionet hetionet:covaries:51249-9013Inferred only
H2AX interacts with TAF1CProteinHetionet hetionet:interacts:3014-9013Inferred only
SET interacts with TAF1CProteinHetionet hetionet:interacts:6418-9013Inferred only
SMN1; SMN2 interacts with TAF1CProteinHetionet hetionet:interacts:6607-9013Inferred only
SMN1; SMN2 interacts with TAF1CProteinHetionet hetionet:interacts:6606-9013Inferred only
TBP interacts with TAF1CProteinHetionet hetionet:interacts:6908-9013Inferred only
TK1 interacts with TAF1CProteinHetionet hetionet:interacts:7083-9013Inferred only

Show the remaining 15

TTR interacts with TAF1CProteinHetionet hetionet:interacts:7276-9013Inferred only
UFD1 interacts with TAF1CProteinHetionet hetionet:interacts:7353-9013Inferred only
TAF1C participates in B-WICH complex positively regulates rRNA expressionPathwayReactome R-HSA-5250924Inferred only
TAF1C participates in Epigenetic regulation of gene expressionPathwayReactome R-HSA-212165Inferred only
TAF1C participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
TAF1C participates in Negative epigenetic regulation of rRNA expressionPathwayReactome R-HSA-5250941Inferred only
TAF1C participates in NoRC negatively regulates rRNA expressionPathwayReactome R-HSA-427413Inferred only
TAF1C participates in Positive epigenetic regulation of rRNA expressionPathwayReactome R-HSA-5250913Inferred only
TAF1C participates in RNA Polymerase I Promoter EscapePathwayReactome R-HSA-73772Inferred only
TAF1C participates in RNA Polymerase I TranscriptionPathwayReactome R-HSA-73864Inferred only
TAF1C participates in RNA Polymerase I Transcription InitiationPathwayReactome R-HSA-73762Inferred only
TAF1C participates in RNA Polymerase I Transcription TerminationPathwayReactome R-HSA-73863Inferred only
TAF1C participates in SIRT1 negatively regulates rRNA expressionPathwayReactome R-HSA-427359Inferred only
TAF1C participates in Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex PathwayWikiPathways WP5565Inferred only
TAF1C regulates regulation of DNA-templated transcriptionBiological processgene ontology Q15572|GO:0006355Inferred only

Other names

5 names

Resolves to: TAF1C

Also called: RNA polymerase I-specific TBP-associated factor 110 kDaTAFI110TATA box-binding protein-associated factor 1CTBP-associated factor 1CTranscription initiation factor SL1/TIF-IB subunit C

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