Proteins/UNIPROT:Q7Z5K2

WAPL

ProteinUNIPROT:Q7Z5K2

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair..

Function from UniProtKB (Q7Z5K2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

30 statements

30 statements · 4 reference databases · Subject: WAPL · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

BAG4 covaries with WAPLProteinHetionet hetionet:covaries:23063-9530Inferred only
INA covaries with WAPLProteinHetionet hetionet:covaries:23063-9118Inferred only
WDR74 covaries with WAPLProteinHetionet hetionet:covaries:23063-54663Inferred only
ZNF19 covaries with WAPLProteinHetionet hetionet:covaries:23063-7567Inferred only
ZNF787 covaries with WAPLProteinHetionet hetionet:covaries:126208-23063Inferred only
WAPL interacts with PDS5AProteinHetionet hetionet:interacts:23063-23244Inferred only
PDS5B interacts with WAPLProteinHetionet hetionet:interacts:23047-23063Inferred only
RAD21 interacts with WAPLProteinHetionet hetionet:interacts:23063-5885Inferred only
SUMO2 interacts with WAPLProteinHetionet hetionet:interacts:23063-6613Inferred only
UBC interacts with WAPLProteinHetionet hetionet:interacts:23063-7316Inferred only
VCP interacts with WAPLProteinHetionet hetionet:interacts:23063-7415Inferred only
WAPL interacts with XRN1ProteinHetionet hetionet:interacts:23063-54464Inferred only

Show the remaining 18

WAPL participates in 10q22q23 copy number variationPathwayWikiPathways WP5402Inferred only
WAPL participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
WAPL participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
WAPL participates in Cohesin complex Cornelia de Lange syndromePathwayWikiPathways WP5117Inferred only
WAPL participates in Cohesin Loading onto ChromatinPathwayReactome R-HSA-2470946Inferred only
WAPL participates in Establishment of Sister Chromatid CohesionPathwayReactome R-HSA-2468052Inferred only
WAPL participates in M PhasePathwayReactome R-HSA-68886Inferred only
WAPL participates in Mitotic AnaphasePathwayReactome R-HSA-68882Inferred only
WAPL participates in Mitotic Metaphase and AnaphasePathwayReactome R-HSA-2555396Inferred only
WAPL participates in Mitotic PrometaphasePathwayReactome R-HSA-68877Inferred only
WAPL participates in Mitotic Telophase/CytokinesisPathwayReactome R-HSA-68884Inferred only
WAPL participates in Resolution of Sister Chromatid CohesionPathwayReactome R-HSA-2500257Inferred only
WAPL participates in S PhasePathwayReactome R-HSA-69242Inferred only
WAPL participates in Separation of Sister ChromatidsPathwayReactome R-HSA-2467813Inferred only
WAPL regulates negative regulation of chromatin bindingBiological processgene ontology Q7Z5K2|GO:0035562Inferred only
WAPL regulates negative regulation of DNA replicationBiological processgene ontology Q7Z5K2|GO:0008156Inferred only
WAPL regulates negative regulation of sister chromatid cohesionBiological processgene ontology Q7Z5K2|GO:0045875Inferred only
ACAA1 increases the expression of WAPLProteinHetionet hetionet:regulates:30-23063Inferred only

Other names

5 names

Resolves to: WAPL

Also called: FOEFriend of EBNA2 proteinKIAA0261WAPALWAPL cohesin release factor

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