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Proteins/UNIPROT:Q8NBT2

SPC24

Protein·UNIPROT:Q8NBT2

Open in the graph

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules..

Function from UniProtKB (Q8NBT2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

29 statements

29 statements · 2 reference databases · Subject: SPC24 · Sources: Hetionet, Reactome

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CKAP2L covaries with SPC24ProteinHetionet hetionet:covaries:147841-150468Inferred only
SPC24 covaries with IL23AProteinHetionet hetionet:covaries:147841-51561Inferred only
SLC17A3 covaries with SPC24ProteinHetionet hetionet:covaries:10786-147841Inferred only
APP interacts with SPC24ProteinHetionet hetionet:interacts:147841-351Inferred only
PSEN2 interacts with SPC24ProteinHetionet hetionet:interacts:147841-5664Inferred only
SPC24 interacts with SKA1ProteinHetionet hetionet:interacts:147841-220134Inferred only
SPC24 interacts with SKA2ProteinHetionet hetionet:interacts:147841-348235Inferred only
SPC24 interacts with SKA3ProteinHetionet hetionet:interacts:147841-221150Inferred only
SPC25 interacts with SPC24ProteinHetionet hetionet:interacts:147841-57405Inferred only
UBC interacts with SPC24ProteinHetionet hetionet:interacts:147841-7316Inferred only
VCP interacts with SPC24ProteinHetionet hetionet:interacts:147841-7415Inferred only
SPC24 participates in Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalPathwayReactome R-HSA-141444Inferred only

Show the remaining 17

SPC24 participates in Amplification of signal from the kinetochoresPathwayReactome R-HSA-141424Inferred only
SPC24 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
SPC24 participates in Cell Cycle CheckpointsPathwayReactome R-HSA-69620Inferred only
SPC24 participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
SPC24 participates in EML4 and NUDC in mitotic spindle formationPathwayReactome R-HSA-9648025Inferred only
SPC24 participates in M PhasePathwayReactome R-HSA-68886Inferred only
SPC24 participates in Mitotic AnaphasePathwayReactome R-HSA-68882Inferred only
SPC24 participates in Mitotic Metaphase and AnaphasePathwayReactome R-HSA-2555396Inferred only
SPC24 participates in Mitotic PrometaphasePathwayReactome R-HSA-68877Inferred only
SPC24 participates in Mitotic Spindle CheckpointPathwayReactome R-HSA-69618Inferred only
SPC24 participates in Resolution of Sister Chromatid CohesionPathwayReactome R-HSA-2500257Inferred only
SPC24 participates in RHO GTPase EffectorsPathwayReactome R-HSA-195258Inferred only
SPC24 participates in RHO GTPases Activate ForminsPathwayReactome R-HSA-5663220Inferred only
SPC24 participates in Separation of Sister ChromatidsPathwayReactome R-HSA-2467813Inferred only
SPC24 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SPC24 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
SPC24 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only

Other names

3 names

Resolves to: SPC24

Also called: hSpc24Kinetochore protein Spc24SPBC24

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