(S)-3-amino-2-methylpropanoate

Three steps

• L-methionineReach from here →
  1. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by ABAT, AGXT2, TYW1B, TYW1mitochondrial matrix

• L-alanineReach from here →
  1. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase
  2. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ABAT, AGXT2mitochondrial matrixOne of 19 routes

• (3S)-citramalyl-CoAReach from here →
  1. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by ABAT, AGXT2, CLYBLmitochondrial matrix

• 5-amino-2-oxopentanoateReach from here →
  1. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by ABAT, AGXT2mitochondrial matrix

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by ABAT, AGXT2, HOGA1mitochondrial matrix

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by ABAT, AGXT2, HOGA1mitochondrial matrix

• 3-methylmalateReach from here →
  1. (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate
  2. 2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by ABAT, ALDH6A1, CLYBL

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by ABAT, AGXT2, PDHA1, PDHB and 1 moremitochondrial matrix