N-formylanthranilic acid

Three steps

• L-phenylalanineReach from here →
  1. N-Formylanthranilate amidohydrolase
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by AFMID, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 2 routes

• N-acetylputrescineReach from here →
  1. N-Formylanthranilate amidohydrolase
  2. transport of acetate and formate (cytosol to extracellular)
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space

• N(8)-acetylspermidineReach from here →
  1. N-Formylanthranilate amidohydrolase
  2. transport of acetate and formate (cytosol to extracellular)
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space

• (3S)-citramalyl-CoAReach from here →
  1. N-Formylanthranilate amidohydrolase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. N-Formylanthranilate amidohydrolase
  2. transport of acetate and formate (cytosol to extracellular)
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space

• 5-amino-2-oxopentanoateReach from here →
  1. N-Formylanthranilate amidohydrolase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• 4-aminobutanoateReach from here →
  1. N-Formylanthranilate amidohydrolase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by AFMID, SLC26A4, SLC6A12cytosol, extracellular spaceOne of 4 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. N-Formylanthranilate amidohydrolase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. N-Formylanthranilate amidohydrolase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. N-Formylanthranilate amidohydrolase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A7 and 5 morecytosol, extracellular space, mitochondrial matrix