3-hydroxyanthranilate

Three steps

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by KYNU, KYAT3, AADAT, GLYATL2One of 2 routes

• an L-alpha-amino acidReach from here →
  1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  2. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
  3. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)

  Catalysed by KYNU, KMO, SLC7A11inner side of the membrane, outer side of the membraneOne of 2 routes

• L-prolineReach from here →
  1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by KYNU, SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes

• N-benzoylglycineReach from here →
  1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by KYNU, KYAT3, AADATmitochondrial matrixOne of 2 routes

• L-cysteinylglycineReach from here →
  1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by KYNU, GGTLC3, GGT1, GGT5 and 3 morecytosolOne of 2 routes

• Mo-molybdopterinReach from here →
  1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by KYNU, MOCOS

• (2S)-2-aminobutanoateReach from here →
  1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  2. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
  3. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O

  Catalysed by KYNU, KMO, AADATOne of 3 routes

• glycodeoxycholateReach from here →
  1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
  3. Glycodeoxycholate amidohydrolase

  Catalysed by KYNU, KYAT3, AADATcytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by KYNU, KYAT3, AADAT, GLYATL2

• N-eicosanoylglycinateReach from here →
  1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by KYNU, KYAT3, AADAT, BAAT

• N-docosanoylglycineReach from here →
  1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by KYNU, KYAT3, AADAT, BAAT

• N-hexacosanoylglycineReach from here →
  1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by KYNU, KYAT3, AADAT, BAAT