tetra-mu3-sulfido-tetrairon(2+)

Three steps

• 3-methyl-2-oxobutanoateReach from here →
  1. lipoyl synthase
  2. transport of methionine and valine (cytosol to extracellular)
  3. L-Valine:2-oxoglutarate aminotransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• 2-phenylpropan-2-olReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 8 moremitochondrial matrix

• (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphateReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• a hydroxy polyunsaturated fatty acidReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix

• AReach from here →
  1. lipoyl synthase
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, cytosolOne of 71 routes

• tauroursodeoxycholateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. tauroursodeoxycholate(in) + glutathione(in) + ATP + H2O = tauroursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membrane

• glycoursodeoxycholateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycoursodeoxycholate(in) + glutathione(in) + ATP + H2O = glycoursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 3 routes

• (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrixOne of 2 routes

• a quinoneReach from here →
  1. lipoyl synthase
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, outer side of the membraneOne of 6 routes

• (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. 11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix

• pregnenolone sulfateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. Steryl-Sulfatase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• androsterone 3alpha-sulfateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, cytosolOne of 3 routes

• prostaglandin H3Reach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• prostaglandin A2-S-(R)-glutathioneReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

• prostaglandin A2-S-(S)-glutathioneReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

• prostaglandin J2-S-(R)-glutathioneReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix

• prostaglandin J2-S-(S)-glutathioneReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

• 13-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• 9-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 8 moremitochondrial matrix

• N-(9Z-octadecenoyl)glycineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosol

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. lipoyl synthase
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. lipoyl synthase
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. lipoyl synthase
  2. transport of leucine and methionine (cytosol to extracellular)
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosol

• N-octadecanoylglycineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• cholesterol sulfateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. Steryl-Sulfatase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• (13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

• 5alpha-dihydrotestosterone sulfateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, cytosolOne of 3 routes

• (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

• 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• 2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• an aryl sulfateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix

• S-methyl glutathioneReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• N-hexadecanoylglycineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• N-dodecanoylglycineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• N-decanoylglycineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• N-octanoylglycineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• D-histidineReach from here →
  1. lipoyl synthase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homoarginineReach from here →
  1. lipoyl synthase
  2. transport of arginine and methionine (cytosol to extracellular)
  3. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-homocarnosineReach from here →
  1. lipoyl synthase
  2. transport of histidine and methionine (cytosol to extracellular)
  3. Formation of homocarnosine

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• 3-(methylthio)propionic acidReach from here →
  1. lipoyl synthase
  2. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
  3. leukotriene-B4 20-monooxygenase (3-(methylthio)propionic acid)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, cytosol

• L-cystine-bis-glycineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosol

• glycyldehydrophenylalanineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• S-adenosylglutathioneReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix