hydrogen sulfide

Three steps

• N-eicosanoylglycinateReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A8 and 1 morecytosol, extracellular space

• N-docosanoylglycineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A8 and 1 morecytosol, extracellular space

• N-hexacosanoylglycineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A8 and 1 morecytosol, extracellular space

• 16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SOD1, STS, CYP3A7

• an N(2)-acyl-L-glutamineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A10 and 2 morecytosol, extracellular space

• (7Z)-hexadecenoyl-CoAReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by CBS, NAGS, SLC27A2, ACSL4 and 6 morecytosol, mitochondrial matrixOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by CBS, NAGS, SLC27A2, ACSL4 and 6 morecytosol, mitochondrial matrixOne of 4 routes

• thromboxane B2Reach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. cystine to cysteine conversion
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by CBS, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O

  Catalysed by TSTD1, PTGES, MGST3, GPX1 and 4 more

• (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by TSTD1, PTGES, MGST3, GPX1 and 4 more

• (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by TSTD1, PTGES, MGST3, GPX1 and 4 more

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by CBS, CTH, PDHA1, PDHB and 1 morecytosol, mitochondrial matrix