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Reach

3,3'-diiodo-L-thyronine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

227 compounds within 3 steps: 6 in 1, 19 in 2, 202 in 3

Does it reach a compound?

Three steps

all-trans-retinyl 9Z-octadecenoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
Catalysed by DIO3, RETSAT, PNPLA4, PNPLA2
(R)-noradrenalineReach from here →
1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
2. transport of GSH and triiodothyronine (cytosol to extracellular)
3. transport of GSH and noradrenaline (cytosol to extracellular)
Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes
di-(9Z)-octadecenoylglycerolReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
Catalysed by DIO3, RETSAT, PNPLA4, PNPLA2
2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by DIO3, RETSAT, LRAT
20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
2. transport of GSH and triiodothyronine (cytosol to extracellular)
3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS1 and 1 more
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS1 and 1 more
9-cis-retinolReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. retinol binding protein (retinol)
Catalysed by DIO3, RETSAT, RBP1, RBP2cytosolOne of 2 routes
ursodeoxycholateReach from here →
1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
2. transport of GSH and triiodothyronine (cytosol to extracellular)
3. transport of GSH and ursodeoxycholate (cytosol to extracellular)
Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
prostaglandin G2Reach from here →
1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
2. transport of GSH and triiodothyronine (cytosol to extracellular)
3. transport of GSH and prostaglandin G2 (cytosol to extracellular)
Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes
thio-Mo-molybdopterinReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, MOCOSOne of 3 routes
2-glyceryl-prostaglandin H2Reach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
thromboxane B2Reach from here →
1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
2. transport of GSH and triiodothyronine (cytosol to extracellular)
3. transport of GSH and thromboxane B2 (cytosol to extracellular)
Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes
prostaglandin H1Reach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS2
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by DIO3, AIFM1, PYROXD1, PTGS1 and 1 more
taurochenodeoxycholateReach from here →
1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
2. transport of GSH and triiodothyronine (cytosol to extracellular)
3. solute carrier organic anion transporter (GSH)
Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

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