Compound
5,6-dihydrouracil
A pyrimidine obtained by formal addition of hydrogen across the 5,6-position of uracil.
Definition from ChEBI (CHEBI:15901), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C4H6N2O2
- Mass
- 114.104 g/mol
- Charge
- 0
- InChIKey
- OIVLITBTBDPEFK-UHFFFAOYSA-N
- SMILES
- O=C1CCNC(=O)N1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
2 entities
2 entities reached.
0 reported hops2 assembled from the scaffold
What the reference databases state
Chemical structure
- 5,6-dihydrouracil has the functional parent uracilCompoundChEBI CHEBI:15901Inferred only
Statements
15 statements
15 statements · 2 reference databases · Subject: 5,6-dihydrouracil · Sources: Human-GEM, Rhea
- 3-(carbamoylamino)propanoate is converted to 5,6-dihydrouracilCompoundRhea RHEA:16121Inferred only
- 5,6-dihydrouracil is converted to 3-(carbamoylamino)propanoateCompoundRhea RHEA:16121Inferred only
- 5,6-dihydrouracil is converted to N-carbamoyl-beta-alanineCompoundHuman-GEM MAR04346Inferred only
- uracil is converted to 5,6-dihydrouracilCompoundHuman-GEM MAR04345Inferred only
- uracil is converted to 5,6-dihydrouracilCompoundRhea RHEA:12384Inferred only
- uracil is converted to 5,6-dihydrouracilCompoundRhea RHEA:18093Inferred only
- uracil is converted to 5,6-dihydrouracilCompoundRhea RHEA:20189Inferred only
- 5,6-dihydrouracil is converted to uracilCompoundHuman-GEM MAR04344Inferred only
- 5,6-dihydrouracil is converted to uracilCompoundHuman-GEM MAR04345Inferred only
- 5,6-dihydrouracil is converted to uracilCompoundRhea RHEA:12384Inferred only
- 5,6-dihydrouracil is converted to uracilCompoundRhea RHEA:20189Inferred only
- uracil is converted to 5,6-dihydrouracilCompoundHuman-GEM MAR04344Inferred only
Show the remaining 3
- 5,6-dihydrouracil is a substrate of DPYDProteinHuman-GEM MAR04345Inferred only
- 5,6-dihydrouracil is a substrate of DPYSProteinHuman-GEM MAR04346Inferred only
- 5,6-dihydrouracil is a substrate of DPYSProteinRhea RHEA:16121Inferred only
Reactions
11 reactions
5,6-dihydrouracil+NAD(+)proton+NADH(2-)+uracil
Reaction pageReversibleBalancedEC 1.3.1.1cytosol
Human-GEM MAR04344CC BY 4.0Reference data
5,6-dihydrouracil+NADP(3-)proton+NADPH(4-)+uracil
Catalysed by DPYD
Reaction pageReversibleBalancedEC 1.3.1.2cytosol
Human-GEM MAR04345CC BY 4.0Reference data
5,6-dihydrouracil+waterN-carbamoyl-beta-alanine+proton
Catalysed by DPYS
Reaction pageLeft to rightBalancedEC 3.5.2.2cytosol
Human-GEM MAR04346CC BY 4.0Reference data
5,6-dihydrouracil+sodium(1+)5,6-dihydrouracil+sodium(1+)
Reaction pageReversibleBalancedEC 3.1.1.4cytosol, extracellular space
Human-GEM MAR09983CC BY 4.0Reference data
5,6-dihydrouracil5,6-dihydrouracil
Reaction pageReversibleBalancedEC 3.1.1.4cytosol, extracellular space
Human-GEM MAR09984CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR10193CC BY 4.0Reference data
CHEBI:142106+diphosphate(3-)5,6-dihydrouracil+5-phospho-alpha-D-ribose 1-diphosphate
Reaction pageDirection not assertedBalanced
Rhea RHEA:10232CC BY 4.0Reference data
5,6-dihydrouracil+dioxygenuracil+hydrogen peroxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:12384CC BY 4.0Reference data
5,6-dihydrouracil+water3-(carbamoylamino)propanoate+hydron
Catalysed by DPYS
Reaction pageDirection not assertedBalanced
Rhea RHEA:16121CC BY 4.0Reference data
5,6-dihydrouracil+NADP(3-)uracil+NADPH(4-)+hydron
Catalysed by DPYD
Reaction pageRight to leftBalanced
Rhea RHEA:18093CC BY 4.0Reference data
5,6-dihydrouracil+NAD(1-)uracil+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:20189CC BY 4.0Reference data
Other names
8 names
Resolves to: 5,6-dihydrouracil
- Also called
- 2,4-Dioxotetrahydropyrimidine2,4(1H,3H)-Pyrimidinedione, dihydro-5,6-Dihydro-2,4-dihydroxypyrimidineDihydro-2,4(1H,3H)-pyrimidinedioneDihydrouracilDihydrouracileHydrouracil
- Systematic name
- dihydropyrimidine-2,4(1H,3H)-dione