Loading the page.
Proteins/UNIPROT:Q8WWT9
High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate. Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic. Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood. Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response..
Function from UniProtKB (Q8WWT9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
1 row
33 statements
33 statements · 7 reference databases · Subject: SLC13A3 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
13 reactions
3sodium(1+)+succinate(2-)3sodium(1+)+succinate(2-)
Transported by SLC13A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04938CC BY 4.0Reference data
2-oxoglutarate(2-)+3sodium(1+)2-oxoglutarate(2-)+3sodium(1+)
Transported by SLC13A3
Reaction pageLeft to rightBalanced
9 names
Resolves to: SLC13A3
Human-GEM MAR05992CC BY 4.0Reference data
citric acid+3sodium(1+)citric acid+3sodium(1+)
Transported by SLC13A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05996CC BY 4.0Reference data
sodium(1+)+MAM02540csodium(1+)+MAM02540e
Transported by SLC13A3
Reaction pageReversibleBalancedEC 3.1.4.2cytosol, extracellular space
Human-GEM MAR10008CC BY 4.0Reference data
succinate(2-)+3sodium(1+)succinate(2-)+3sodium(1+)
Transported by SLC13A2 or SLC13A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:71919CC BY 4.0Reference data
fumaric acid+3sodium(1+)fumaric acid+3sodium(1+)
Transported by SLC13A2 or SLC13A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:71931CC BY 4.0Reference data
2-oxoglutarate(2-)+3sodium(1+)2-oxoglutarate(2-)+3sodium(1+)
Transported by SLC13A2 or SLC13A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:71939CC BY 4.0Reference data
N-acetyl-L-aspartate+3sodium(1+)N-acetyl-L-aspartate+3sodium(1+)
Transported by SLC13A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:71947CC BY 4.0Reference data
glutarate+3sodium(1+)glutarate+3sodium(1+)
Transported by SLC13A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:71955CC BY 4.0Reference data
CHEBI:191383+3sodium(1+)CHEBI:191383+3sodium(1+)
Transported by SLC13A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:72287CC BY 4.0Reference data
CHEBI:191384+3sodium(1+)CHEBI:191384+3sodium(1+)
Transported by SLC13A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:72291CC BY 4.0Reference data
malic acid+3sodium(1+)malic acid+3sodium(1+)
Transported by SLC13A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:72295CC BY 4.0Reference data