Papers/PMID:41799776
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.
International journal of medical sciences2026The record
15 findings · 1 compound · 15 endpoints · 11 null
What it reported
How to read these marksWhat moved
4 findings
Sesamum indicum — decreases systolic blood pressure (setting unspecified)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Sesame supplementation demonstrated a small yet statistically significant reduction in systolic blood pressure (SMD -0.425, 95% CI -0.669 to -0.180, p = 0.001; I² < 0.001%, p = 0.571) and diastolic blood pressure (SMD -0.405, 95% CI -0.687 to -0.123, p = 0.005; I² = 22.784%, p = 0.263).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.425 standardised mean difference, 95% CI -0.669 to -0.18
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Sesamum indicum — decreases diastolic blood pressure (setting unspecified)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Sesame supplementation demonstrated a small yet statistically significant reduction in systolic blood pressure (SMD -0.425, 95% CI -0.669 to -0.180, p = 0.001; I² < 0.001%, p = 0.571) and diastolic blood pressure (SMD -0.405, 95% CI -0.687 to -0.123, p = 0.005; I² = 22.784%, p = 0.263).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.405 standardised mean difference, 95% CI -0.687 to -0.123
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Sesamum indicum — decreases fasting blood glucose
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Sesame supplementation was associated with a modest but significant reduction in fasting blood glucose levels (SMD -0.300, 95% CI -0.560 to -0.040; I² < 0.001%, p = 0.531; Figure 5A) and exhibited a moderate effect on HbA1c (SMD -0.658, 95% CI -1.163 to -0.154; I² = 56.273%, p = 0.102; Figure 5C).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.3 standardised mean difference, 95% CI -0.56 to -0.04
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Sesamum indicum — decreases alanine aminotransferase
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Regarding liver function indicators, sesame supplementation showed a moderate and significant reduction in ALT levels (SMD -0.636, 95% CI -0.956 to -0.316; I² < 0.001%, p = 0.994; Figure 9B), whereas no significant effect was observed on AST levels (SMD -0.384, 95% CI -0.829 to 0.062; I² = 49.039%, p = 0.141; Figure 9A).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.636 standardised mean difference, 95% CI -0.956 to -0.316
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
What did not
11 findings
Sesamum indicum — no detected effect on body mass index
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Sesame supplementation showed no significant effects on body weight (SMD -0.111, 95% CI -0.384 to 0.162; I² < 0.001%, p = 0.837; Figure 6A), BMI (SMD -0.137, 95% CI -0.468 to 0.195; I² < 0.001%, p = 0.436; Figure 6B), body fat percentage (SMD -0.175, 95% CI -0.667 to 0.316; I² = 53.803%, p = 0.115; Figure 6C), waist circumference (SMD -0.054, 95% CI -0.396 to 0.288; I² = 5.879%, p = 0.346; Figure 7A), or hip circumference (SMD -0.096, 95% CI -0.427 to 0.235; I² < 0.001%, p = 0.538; Figure 7B).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.137 standardised mean difference, 95% CI -0.468 to 0.195
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Sesamum indicum — no detected effect on waist circumference
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Sesame supplementation showed no significant effects on body weight (SMD -0.111, 95% CI -0.384 to 0.162; I² < 0.001%, p = 0.837; Figure 6A), BMI (SMD -0.137, 95% CI -0.468 to 0.195; I² < 0.001%, p = 0.436; Figure 6B), body fat percentage (SMD -0.175, 95% CI -0.667 to 0.316; I² = 53.803%, p = 0.115; Figure 6C), waist circumference (SMD -0.054, 95% CI -0.396 to 0.288; I² = 5.879%, p = 0.346; Figure 7A), or hip circumference (SMD -0.096, 95% CI -0.427 to 0.235; I² < 0.001%, p = 0.538; Figure 7B).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.054 standardised mean difference, 95% CI -0.396 to 0.288
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Sesamum indicum — no detected effect on total cholesterol (TC)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Sesame supplementation did not significantly affect serum cholesterol levels (SMD -0.480, 95% CI -1.047 to 0.088; I² = 80.983%, p < 0.001; Figure 8A), triglycerides (SMD -0.333, 95% CI -0.777 to 0.111; I² = 69.801%, p < 0.001; Figure 8B), LDL cholesterol (SMD -0.380, 95% CI -0.766 to 0.006; I² = 59.978%, p = 0.041; Figure 8C), or HDL cholesterol (SMD 0.178, 95% CI -0.236 to 0.591; I² = 55.758%, p = 0.079; Figure 8D).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.48 standardised mean difference, 95% CI -1.047 to 0.088
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Sesamum indicum — no detected effect on triglycerides
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Sesame supplementation did not significantly affect serum cholesterol levels (SMD -0.480, 95% CI -1.047 to 0.088; I² = 80.983%, p < 0.001; Figure 8A), triglycerides (SMD -0.333, 95% CI -0.777 to 0.111; I² = 69.801%, p < 0.001; Figure 8B), LDL cholesterol (SMD -0.380, 95% CI -0.766 to 0.006; I² = 59.978%, p = 0.041; Figure 8C), or HDL cholesterol (SMD 0.178, 95% CI -0.236 to 0.591; I² = 55.758%, p = 0.079; Figure 8D).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.333 standardised mean difference, 95% CI -0.777 to 0.111
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Sesamum indicum — no detected effect on LDL cholesterol
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Sesame supplementation did not significantly affect serum cholesterol levels (SMD -0.480, 95% CI -1.047 to 0.088; I² = 80.983%, p < 0.001; Figure 8A), triglycerides (SMD -0.333, 95% CI -0.777 to 0.111; I² = 69.801%, p < 0.001; Figure 8B), LDL cholesterol (SMD -0.380, 95% CI -0.766 to 0.006; I² = 59.978%, p = 0.041; Figure 8C), or HDL cholesterol (SMD 0.178, 95% CI -0.236 to 0.591; I² = 55.758%, p = 0.079; Figure 8D).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.38 standardised mean difference, 95% CI -0.766 to 0.006
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Sesamum indicum — no detected effect on HDL cholesterol
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Sesame supplementation did not significantly affect serum cholesterol levels (SMD -0.480, 95% CI -1.047 to 0.088; I² = 80.983%, p < 0.001; Figure 8A), triglycerides (SMD -0.333, 95% CI -0.777 to 0.111; I² = 69.801%, p < 0.001; Figure 8B), LDL cholesterol (SMD -0.380, 95% CI -0.766 to 0.006; I² = 59.978%, p = 0.041; Figure 8C), or HDL cholesterol (SMD 0.178, 95% CI -0.236 to 0.591; I² = 55.758%, p = 0.079; Figure 8D).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect 0.178 standardised mean difference, 95% CI -0.236 to 0.591
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Show the remaining 5
Sesamum indicum — no detected effect on aspartate aminotransferase
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Regarding liver function indicators, sesame supplementation showed a moderate and significant reduction in ALT levels (SMD -0.636, 95% CI -0.956 to -0.316; I² < 0.001%, p = 0.994; Figure 9B), whereas no significant effect was observed on AST levels (SMD -0.384, 95% CI -0.829 to 0.062; I² = 49.039%, p = 0.141; Figure 9A).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.384 standardised mean difference, 95% CI -0.829 to 0.062
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Sesamum indicum — no detected effect on tumour necrosis factor alpha concentration
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Sesame supplementation did not significantly influence the levels of pro-inflammatory cytokines, including TNF-α (SMD -0.421, 95% CI -1.199 to 0.356; I² = 74.716%, p = 0.047; Figure 10A), IL-6 (SMD -0.285, 95% CI -0.662 to 0.091; I² < 0.001%, p = 0.390; Figure 10B), or hs-CRP (SMD -0.203, 95% CI -0.487 to 0.080; I² < 0.001%, p = 0.984; Figure 10C).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.421 standardised mean difference, 95% CI -1.199 to 0.356
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Sesamum indicum — no detected effect on interleukin-6 concentration
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Sesame supplementation did not significantly influence the levels of pro-inflammatory cytokines, including TNF-α (SMD -0.421, 95% CI -1.199 to 0.356; I² = 74.716%, p = 0.047; Figure 10A), IL-6 (SMD -0.285, 95% CI -0.662 to 0.091; I² < 0.001%, p = 0.390; Figure 10B), or hs-CRP (SMD -0.203, 95% CI -0.487 to 0.080; I² < 0.001%, p = 0.984; Figure 10C).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.285 standardised mean difference, 95% CI -0.662 to 0.091
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Sesamum indicum — no detected effect on C-reactive protein concentration
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Sesame supplementation did not significantly influence the levels of pro-inflammatory cytokines, including TNF-α (SMD -0.421, 95% CI -1.199 to 0.356; I² = 74.716%, p = 0.047; Figure 10A), IL-6 (SMD -0.285, 95% CI -0.662 to 0.091; I² < 0.001%, p = 0.390; Figure 10B), or hs-CRP (SMD -0.203, 95% CI -0.487 to 0.080; I² < 0.001%, p = 0.984; Figure 10C).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.203 standardised mean difference, 95% CI -0.487 to 0.08
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink
Sesamum indicum — no detected effect on HOMA-IR
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“However, sesame had no significant impact on fasting serum insulin levels (SMD -0.125, 95% CI -0.463 to 0.214; I² = 20.494%, p = 0.287; Figure 5B) or on HOMA-IR values (SMD -0.019, 95% CI -0.368 to 0.329; I² < 0.001%, p = 0.867; Figure 5D).”
Quoted verbatim from Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.. - Study
- meta-analysis
- Population
- Adults with metabolic disorders in 10 pooled RCTs of sesame-based interventions versus placebo or control
Effect -0.019 standardised mean difference, 95% CI -0.368 to 0.329
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.2026PMID:41799776Permalink