Proteins/UNIPROT:Q32MZ4

LRRFIP1

ProteinUNIPROT:Q32MZ4

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding..

Function from UniProtKB (Q32MZ4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

21 statements

21 statements · 4 reference databases · Subject: LRRFIP1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

LRRFIP1 covaries with FFAR3ProteinHetionet hetionet:covaries:2865-9208Inferred only
LRRFIP1 covaries with MAST2ProteinHetionet hetionet:covaries:23139-9208Inferred only
PGGHG covaries with LRRFIP1ProteinHetionet hetionet:covaries:80162-9208Inferred only
LRRFIP1 covaries with PLCH2ProteinHetionet hetionet:covaries:9208-9651Inferred only
LRRFIP1 covaries with PYCR1ProteinHetionet hetionet:covaries:5831-9208Inferred only
LRRFIP1 covaries with TATProteinHetionet hetionet:covaries:6898-9208Inferred only
TMEM132D covaries with LRRFIP1ProteinHetionet hetionet:covaries:121256-9208Inferred only
YTHDF1 covaries with LRRFIP1ProteinHetionet hetionet:covaries:54915-9208Inferred only
FLII interacts with LRRFIP1ProteinHetionet hetionet:interacts:2314-9208Inferred only
LRRFIP1 participates in 2q37 copy number variation syndromePathwayWikiPathways WP5224Inferred only
LRRFIP1 participates in Cytosolic sensors of pathogen-associated DNAPathwayReactome R-HSA-1834949Inferred only
LRRFIP1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only

Show the remaining 9

LRRFIP1 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
LRRFIP1 participates in FGFR1 mutant receptor activationPathwayReactome R-HSA-1839124Inferred only
LRRFIP1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
LRRFIP1 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
LRRFIP1 participates in LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN productionPathwayReactome R-HSA-3134973Inferred only
LRRFIP1 participates in Signaling by cytosolic FGFR1 fusion mutantsPathwayReactome R-HSA-1839117Inferred only
LRRFIP1 participates in Signaling by FGFR in diseasePathwayReactome R-HSA-1226099Inferred only
LRRFIP1 participates in Signaling by FGFR1 in diseasePathwayReactome R-HSA-5655302Inferred only
LRRFIP1 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q32MZ4|GO:0000122Inferred only

Other names

5 names

Resolves to: LRRFIP1

Also called: GC-binding factor 2GCF2LRR FLII-interacting protein 1TAR RNA-interacting proteinTRIP

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