Pathway
Tyrosine catabolism
Cytosolic tyrosine is transaminated to form 3-(4-hydroxyphenyl)pyruvate which in four further reactions is converted to fumarate and acetoacetate. Tyrosine is thus both a glucogenic (fumarate) and a ketogenic (acetoacetate) amino acid. Defects in any of the steps lead to metabolic diseases with accumulation of tyrosine (tyrosinemia).
REACT:R-HSA-8963684Reactome
What the reference databases state
Statements
5 statements
5 statements · 1 reference database · Subject: Tyrosine catabolism · Sources: Reactome
- FAH participates in Tyrosine catabolismProteinReactome R-HSA-8963684Inferred only
- GSTZ1 participates in Tyrosine catabolismProteinReactome R-HSA-8963684Inferred only
- HGD participates in Tyrosine catabolismProteinReactome R-HSA-8963684Inferred only
- HPD participates in Tyrosine catabolismProteinReactome R-HSA-8963684Inferred only
- TAT participates in Tyrosine catabolismProteinReactome R-HSA-8963684Inferred only