Pathway
Impaired BRCA2 binding to RAD51
A critical function of BRCA2 is to bind RAD51 and nucleate RAD51 filament formation on single-stranded DNA. BRCA2 has two regions that interact with RAD51: 8 BRC repeats encoded by exon11 and a C-terminal RAD51 binding domain called TR2.
REACT:R-HSA-9709570Reactome
What the reference databases state
Statements
35 statements
35 statements · 1 reference database · Subject: Impaired BRCA2 binding to RAD51 · Sources: Reactome
- ATM participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- ATR participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- ATRIP participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- BARD1 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- BLM participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- BRCA1 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- BRCA2 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- BRIP1 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- DNA2 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- EXO1 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- HUS1 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- KAT5 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
Show the remaining 23
- MRE11 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- NBN participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RAD1 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RAD17 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RAD50 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RAD51 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RAD9A participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RAD9B participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RBBP8 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RFC2 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RFC3 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RFC4 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RFC5 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RHNO1 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RMI1 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RMI2 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RPA1 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RPA2 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- RPA3 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- SEM1 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- TOP3A participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- TOPBP1 participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only
- WRN participates in Impaired BRCA2 binding to RAD51ProteinReactome R-HSA-9709570Inferred only