Pathway
Presynaptic phase of homologous DNA pairing and strand exchange
The presynaptic phase of homologous DNA pairing and strand exchange during homologous recombination repair (HRR) begins with the displacement of RPA from ssDNA by the joint action of RAD51 and BRCA2. CHEK1-mediated phosphorylation of RAD51 and BRCA2 is needed for BRCA2-mediated nucleation of RAD51 on 3'-ssDNA overhangs, RPA displacement and formation of RAD51 nucleofilaments. Invasive RAD51 nucleofilaments are stabilized by the BCDX2 complex composed of RAD51B, RAD51C, RAD51D and XRCC2.
REACT:R-HSA-5693616Reactome
What the reference databases state
Statements
40 statements
40 statements · 1 reference database · Subject: Presynaptic phase of homologous DNA pairing and strand exchange · Sources: Reactome
- ATM participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- ATR participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- ATRIP participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- BARD1 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- BLM participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- BRCA1 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- BRCA2 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- BRIP1 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- CHEK1 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- DNA2 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- EXO1 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- HUS1 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
Show the remaining 28
- KAT5 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- MRE11 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- NBN participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RAD1 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RAD17 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RAD50 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RAD51 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RAD51B participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RAD51C participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RAD51D participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RAD9A participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RAD9B participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RBBP8 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RFC2 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RFC3 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RFC4 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RFC5 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RHNO1 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RMI1 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RMI2 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RPA1 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RPA2 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- RPA3 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- SEM1 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- TOP3A participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- TOPBP1 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- WRN participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only
- XRCC2 participates in Presynaptic phase of homologous DNA pairing and strand exchangeProteinReactome R-HSA-5693616Inferred only