Loading the page.
Proteins/UNIPROT:Q9BT30
RNA demethylase that demethylates N(2)-dimethylguanosine and N(1)-methyladenosine within mitochondrial pre-tRNA regions. This demethylation activity plays a crucial role in regulating the processing of nascent polycistronic mitochondrial RNA, thereby influencing mitochondrial gene expression and overall mitochondrial activity. In response to extensive DNA damage is required for programmed necrosis induced by alkylation and oxidation. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. Involved in fatty acid metabolism (By similarity)..
Function from UniProtKB (Q9BT30), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
47 statements
47 statements · 4 reference databases · Subject: ALKBH7 · Sources: Bgee, gene ontology, Hetionet, UniProt
2 reactions
an N(1)-methyladenosine in tRNA+2-oxoglutarate(2-)+dioxygenan adenosine in tRNA+formaldehyde+succinate(2-)+carbon dioxide
Catalysed by ALKBH1 or ALKBH7 or FTO
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54576CC BY 4.0Reference data
CHEBI:74513+22-oxoglutarate(2-)+2dioxygen
8 names
Resolves to: ALKBH7
Catalysed by ALKBH7
Reaction pageLeft to rightBalanced
Rhea RHEA:85431CC BY 4.0Reference data