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Proteins/UNIPROT:P50583
Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (By similarity). Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (By similarity)..
Function from UniProtKB (P50583), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
13 statements
13 statements · 5 reference databases · Subject: NUDT2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt
5 reactions
water+P(1),P(4)-bis(5'-guanosyl) tetraphosphateGMP+GTP+2proton
Catalysed by NUDT2
Reaction pageLeft to rightBalancedEC 3.6.1.17cytosol
Human-GEM MAR09484CC BY 4.0Reference data
water+P(1),P(4)-bis(5'-adenosyl) tetraphosphateAMP+ATP+2proton
Catalysed by NUDT2
8 names
Resolves to: NUDT2
Reaction pageLeft to rightBalancedEC 3.6.1.17cytosol
Human-GEM MAR09570CC BY 4.0Reference data
P(1),P(4)-bis(5'-guanosyl) tetraphosphate+waterGMP+GTP+2hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:22484CC BY 4.0Reference data
a 5'-end FAD-phospho-ribonucleoside in mRNA+watera 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA+FMN+2hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67588CC BY 4.0Reference data
a 5'-end CoA-ribonucleoside in mRNA+watera 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA+(R)-4'-phosphopantetheine+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT2 or NUDT8 or NUDT16 or NUDT15
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67592CC BY 4.0Reference data