Proteins/UNIPROT:Q9NPP4

NLRC4

ProteinUNIPROT:Q9NPP4

Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity)..

Function from UniProtKB (Q9NPP4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

familial cold autoinflammatory syndrome 4 has a germline basis in NLRC4DiseaseGenCC HGNC:16412|MONDO:0014498Inferred only
periodic fever-infantile enterocolitis-autoinflammatory syndrome has a germline basis in NLRC4DiseaseGenCC HGNC:16412|MONDO:0014472Inferred only

Statements

80 statements

80 statements · 4 reference databases · Subject: NLRC4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

NLRC4 covaries with AMOTL1ProteinHetionet hetionet:covaries:154810-58484Inferred only
NLRC4 covaries with ARFGEF2ProteinHetionet hetionet:covaries:10564-58484Inferred only
NLRC4 covaries with BTG1ProteinHetionet hetionet:covaries:58484-694Inferred only
NLRC4 covaries with BUD31ProteinHetionet hetionet:covaries:58484-8896Inferred only
NLRC4 covaries with CENPLProteinHetionet hetionet:covaries:58484-91687Inferred only
NLRC4 covaries with CENPSProteinHetionet hetionet:covaries:100526739-58484Inferred only
NLRC4 covaries with CEP350ProteinHetionet hetionet:covaries:58484-9857Inferred only
NLRC4 covaries with DARS2ProteinHetionet hetionet:covaries:55157-58484Inferred only
NLRC4 covaries with DEUP1ProteinHetionet hetionet:covaries:159989-58484Inferred only
NLRC4 covaries with DPH2ProteinHetionet hetionet:covaries:1802-58484Inferred only
NLRC4 covaries with ENTPD7ProteinHetionet hetionet:covaries:57089-58484Inferred only
NLRC4 covaries with ESPL1ProteinHetionet hetionet:covaries:58484-9700Inferred only

Show the remaining 68

NLRC4 covaries with EXOSC10ProteinHetionet hetionet:covaries:5394-58484Inferred only
NLRC4 covaries with FGF9ProteinHetionet hetionet:covaries:2254-58484Inferred only
NLRC4 covaries with FLACC1ProteinHetionet hetionet:covaries:130540-58484Inferred only
NLRC4 covaries with FOSL2ProteinHetionet hetionet:covaries:2355-58484Inferred only
NLRC4 covaries with GABPB2ProteinHetionet hetionet:covaries:126626-58484Inferred only
NLRC4 covaries with GPR18ProteinHetionet hetionet:covaries:2841-58484Inferred only
NLRC4 covaries with HEATR5BProteinHetionet hetionet:covaries:54497-58484Inferred only
NLRC4 covaries with HERC1ProteinHetionet hetionet:covaries:58484-8925Inferred only
NLRC4 covaries with HPGDSProteinHetionet hetionet:covaries:27306-58484Inferred only
NLRC4 covaries with INTS7ProteinHetionet hetionet:covaries:25896-58484Inferred only
NLRC4 covaries with INTUProteinHetionet hetionet:covaries:27152-58484Inferred only
NLRC4 covaries with KIF13AProteinHetionet hetionet:covaries:58484-63971Inferred only
NLRC4 covaries with LSM5ProteinHetionet hetionet:covaries:23658-58484Inferred only
NLRC4 covaries with MACIRProteinHetionet hetionet:covaries:58484-90355Inferred only
NLRC4 covaries with MARS1ProteinHetionet hetionet:covaries:4141-58484Inferred only
NLRC4 covaries with MLH3ProteinHetionet hetionet:covaries:27030-58484Inferred only
NLRC4 covaries with MTCH1ProteinHetionet hetionet:covaries:23787-58484Inferred only
NLRC4 covaries with NOP2ProteinHetionet hetionet:covaries:4839-58484Inferred only
NLRC4 covaries with NRBP1ProteinHetionet hetionet:covaries:29959-58484Inferred only
NLRC4 covaries with PDCD11ProteinHetionet hetionet:covaries:22984-58484Inferred only
NLRC4 covaries with PIGSProteinHetionet hetionet:covaries:58484-94005Inferred only
NLRC4 covaries with PIH1D2ProteinHetionet hetionet:covaries:120379-58484Inferred only
NLRC4 covaries with PLB1ProteinHetionet hetionet:covaries:151056-58484Inferred only
NLRC4 covaries with PPIL1ProteinHetionet hetionet:covaries:51645-58484Inferred only
NLRC4 covaries with PREPLProteinHetionet hetionet:covaries:58484-9581Inferred only
NLRC4 covaries with PRMT9ProteinHetionet hetionet:covaries:58484-90826Inferred only
NLRC4 covaries with RNF169ProteinHetionet hetionet:covaries:254225-58484Inferred only
NLRC4 covaries with RNF214ProteinHetionet hetionet:covaries:257160-58484Inferred only
NLRC4 covaries with RPL23ProteinHetionet hetionet:covaries:58484-9349Inferred only
NLRC4 covaries with RPS13ProteinHetionet hetionet:covaries:58484-6207Inferred only
NLRC4 covaries with SMYD5ProteinHetionet hetionet:covaries:10322-58484Inferred only
NLRC4 covaries with STEAP1ProteinHetionet hetionet:covaries:26872-58484Inferred only
NLRC4 covaries with SYT14ProteinHetionet hetionet:covaries:255928-58484Inferred only
NLRC4 covaries with TBL1XR1ProteinHetionet hetionet:covaries:58484-79718Inferred only
TGIF2 covaries with NLRC4ProteinHetionet hetionet:covaries:58484-60436Inferred only
NLRC4 covaries with TMPRSS12ProteinHetionet hetionet:covaries:283471-58484Inferred only
NLRC4 covaries with TOR2AProteinHetionet hetionet:covaries:27433-58484Inferred only
NLRC4 covaries with TUBB2AProteinHetionet hetionet:covaries:58484-7280Inferred only
NLRC4 covaries with UBR7ProteinHetionet hetionet:covaries:55148-58484Inferred only
NLRC4 covaries with WIZProteinHetionet hetionet:covaries:58484-58525Inferred only
NLRC4 covaries with YIF1AProteinHetionet hetionet:covaries:10897-58484Inferred only
NLRC4 covaries with ZNF112ProteinHetionet hetionet:covaries:58484-7771Inferred only
NLRC4 covaries with ZNF354AProteinHetionet hetionet:covaries:58484-6940Inferred only
BCL10 interacts with NLRC4ProteinHetionet hetionet:interacts:58484-8915Inferred only
CASP1 interacts with NLRC4ProteinHetionet hetionet:interacts:58484-834Inferred only
CASP8 interacts with NLRC4ProteinHetionet hetionet:interacts:58484-841Inferred only
NLRC4 interacts with NLRP3ProteinHetionet hetionet:interacts:114548-58484Inferred only
NLRC4 interacts with NLRP4ProteinHetionet hetionet:interacts:147945-58484Inferred only
NOD1 interacts with NLRC4ProteinHetionet hetionet:interacts:10392-58484Inferred only
NLRC4 interacts with NOD2ProteinHetionet hetionet:interacts:58484-64127Inferred only
PSMC5 interacts with NLRC4ProteinHetionet hetionet:interacts:5705-58484Inferred only
PYCARD interacts with NLRC4ProteinHetionet hetionet:interacts:29108-58484Inferred only
NLRC4 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
NLRC4 participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
NLRC4 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
NLRC4 participates in InflammasomesPathwayReactome R-HSA-622312Inferred only
NLRC4 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
NLRC4 participates in Nucleotide binding oligomerization domain NOD pathwayPathwayWikiPathways WP1433Inferred only
NLRC4 participates in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysPathwayReactome R-HSA-168643Inferred only
NLRC4 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
NLRC4 participates in The IPAF inflammasomePathwayReactome R-HSA-844623Inferred only
NLRC4 participates in TP53 Regulates Transcription of Caspase Activators and CaspasesPathwayReactome R-HSA-6803207Inferred only
NLRC4 participates in TP53 Regulates Transcription of Cell Death GenesPathwayReactome R-HSA-5633008Inferred only
NLRC4 participates in Transcriptional Regulation by TP53PathwayReactome R-HSA-3700989Inferred only
NLRC4 regulates positive regulation of apoptotic processBiological processgene ontology Q9NPP4|GO:0043065Inferred only
NLRC4 regulates positive regulation of inflammatory responseBiological processgene ontology Q9NPP4|GO:0050729Inferred only
NLRC4 regulates positive regulation of interleukin-1 beta productionBiological processgene ontology Q9NPP4|GO:0032731Inferred only
NLRC4 regulates positive regulation of protein processingBiological processgene ontology Q9NPP4|GO:0010954Inferred only

Other names

8 names

Resolves to: NLRC4

Also called: CARD, LRR, and NACHT-containing proteinCARD12Caspase recruitment domain-containing protein 12CED-4-like protein ClanCLANCLAN1Ice protease-activating factorIPAF

← Every protein Find it in the graph →