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Proteins/UNIPROT:Q9BU89
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity)..
Function from UniProtKB (Q9BU89), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
31 statements
31 statements · 5 reference databases · Subject: DOHH · Sources: Bgee, Hetionet, Reactome, Rhea, UniProt
1 reaction
[eIF5A protein]-deoxyhypusine+AH2+dioxygen[eIF5A protein]-hypusine+A+water
Catalysed by DOHH
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:14101CC BY 4.0Reference data
5 names
Resolves to: DOHH