Proteins/UNIPROT:O75553

DAB1

ProteinUNIPROT:O75553

Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain..

Function from UniProtKB (O75553), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

spinocerebellar ataxia type 37 has a germline basis in DAB1DiseaseGenCC HGNC:2661|MONDO:0014410Inferred only

Statements

35 statements

35 statements · 4 reference databases · Subject: DAB1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

APLP1 interacts with DAB1ProteinHetionet hetionet:interacts:1600-333Inferred only
APLP2 interacts with DAB1ProteinHetionet hetionet:interacts:1600-334Inferred only
APP interacts with DAB1ProteinHetionet hetionet:interacts:1600-351Inferred only
CDK5 interacts with DAB1ProteinHetionet hetionet:interacts:1020-1600Inferred only
CRK interacts with DAB1ProteinHetionet hetionet:interacts:1398-1600Inferred only
CRKL interacts with DAB1ProteinHetionet hetionet:interacts:1399-1600Inferred only
DAB1 interacts with DAB2IPProteinHetionet hetionet:interacts:153090-1600Inferred only
DAB1 interacts with INPP5DProteinHetionet hetionet:interacts:1600-3635Inferred only
DAB1 interacts with ITGB2ProteinHetionet hetionet:interacts:1600-3689Inferred only
DAB1 interacts with ITGB3ProteinHetionet hetionet:interacts:1600-3690Inferred only
DAB1 interacts with ITGB5ProteinHetionet hetionet:interacts:1600-3693Inferred only
DAB1 interacts with ITGB7ProteinHetionet hetionet:interacts:1600-3695Inferred only

Show the remaining 23

DAB1 interacts with LDLRProteinHetionet hetionet:interacts:1600-3949Inferred only
DAB1 interacts with LRP1ProteinHetionet hetionet:interacts:1600-4035Inferred only
DAB1 interacts with LRP2ProteinHetionet hetionet:interacts:1600-4036Inferred only
DAB1 interacts with LRP8ProteinHetionet hetionet:interacts:1600-7804Inferred only
DAB1 interacts with MYO6ProteinHetionet hetionet:interacts:1600-4646Inferred only
DAB1 interacts with PAFAH1B1ProteinHetionet hetionet:interacts:1600-5048Inferred only
DAB1 interacts with PCDH18ProteinHetionet hetionet:interacts:1600-54510Inferred only
DAB1 interacts with PLCG1ProteinHetionet hetionet:interacts:1600-5335Inferred only
DAB1 interacts with PTPN11ProteinHetionet hetionet:interacts:1600-5781Inferred only
DAB1 interacts with RELNProteinHetionet hetionet:interacts:1600-5649Inferred only
DAB1 interacts with SH3KBP1ProteinHetionet hetionet:interacts:1600-30011Inferred only
DAB1 interacts with SIAH1ProteinHetionet hetionet:interacts:1600-6477Inferred only
DAB1 interacts with SOCS1ProteinHetionet hetionet:interacts:1600-8651Inferred only
DAB1 interacts with SOCS3ProteinHetionet hetionet:interacts:1600-9021Inferred only
DAB1 interacts with SRCProteinHetionet hetionet:interacts:1600-6714Inferred only
DAB1 interacts with VLDLRProteinHetionet hetionet:interacts:1600-7436Inferred only
DAB1 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
DAB1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
DAB1 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
DAB1 participates in Neurogenesis regulation in the olfactory epitheliumPathwayWikiPathways WP5265Inferred only
DAB1 participates in Reelin signalling pathwayPathwayReactome R-HSA-8866376Inferred only
DAB1 participates in Splicing factor NOVA regulated synaptic proteinsPathwayWikiPathways WP4148Inferred only
DAB1 regulates regulation of synapse maturationBiological processgene ontology O75553|GO:0090128Inferred only

Other names

1 name

Resolves to: DAB1

Also called: Disabled homolog 1

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