Developmental Lineage of Multipotent Pancreatic Progenitor Cells

Definitive endoderm forms during gastrulation and then undergoes patterning along anterior/posterior, dorsal/ventral, and median/lateral axes. Definitive endoderm cells produce, among other embryonal cell types, endoderm cells of dorsal and ventral foregut. The dorsal foregut endoderm cells, which transition through an intermediary duodeno-pancreatic endoderm cell state, and the ventral foregut endoderm cells, which possibly transition through a hepato-pancreatic or pancreato-biliary intermediary state, give rise to primary multipotent pancreatic progenitor cells (MPCs) that form dorsal and ventral pancreatic buds, respectively (Yu et al. 2019, reviewed in Jennings et al. 2015).

Summary from Reactome (R-HSA-9937080), read 2026-09-23.