Proteins/UNIPROT:Q9Y5Q8

GTF3C5

ProteinUNIPROT:Q9Y5Q8

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Function from UniProtKB (Q9Y5Q8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

complex neurodevelopmental disorder has a germline basis in GTF3C5DiseaseGenCC HGNC:4668|MONDO:0100038Inferred only
neurodevelopmental disorder has a germline basis in GTF3C5DiseaseGenCC HGNC:4668|MONDO:0700092Inferred only

Statements

23 statements

23 statements · 2 reference databases · Subject: GTF3C5 · Sources: Hetionet, Reactome

Order

GTF3C5 covaries with BRAT1ProteinHetionet hetionet:covaries:221927-9328Inferred only
GTF3C5 covaries with GTF3C3ProteinHetionet hetionet:covaries:9328-9330Inferred only
BRF1 interacts with GTF3C5ProteinHetionet hetionet:interacts:2972-9328Inferred only
CUL1 interacts with GTF3C5ProteinHetionet hetionet:interacts:8454-9328Inferred only
CUL3 interacts with GTF3C5ProteinHetionet hetionet:interacts:8452-9328Inferred only
GTF3C2 interacts with GTF3C5ProteinHetionet hetionet:interacts:2976-9328Inferred only
GTF3C5 interacts with GTF3C3ProteinHetionet hetionet:interacts:9328-9330Inferred only
GTF3C5 interacts with GTF3C4ProteinHetionet hetionet:interacts:9328-9329Inferred only
GTF3C5 interacts with GTF3C6ProteinHetionet hetionet:interacts:112495-9328Inferred only
MTOR interacts with GTF3C5ProteinHetionet hetionet:interacts:2475-9328Inferred only
GTF3C5 interacts with PAXIP1ProteinHetionet hetionet:interacts:22976-9328Inferred only
GTF3C5 interacts with SRA1ProteinHetionet hetionet:interacts:10011-9328Inferred only

Show the remaining 11

TBP interacts with GTF3C5ProteinHetionet hetionet:interacts:6908-9328Inferred only
TCF21 interacts with GTF3C5ProteinHetionet hetionet:interacts:6943-9328Inferred only
TCF4 interacts with GTF3C5ProteinHetionet hetionet:interacts:6925-9328Inferred only
UBC interacts with GTF3C5ProteinHetionet hetionet:interacts:7316-9328Inferred only
VCP interacts with GTF3C5ProteinHetionet hetionet:interacts:7415-9328Inferred only
GTF3C5 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
GTF3C5 participates in RNA Polymerase III Abortive And Retractive InitiationPathwayReactome R-HSA-749476Inferred only
GTF3C5 participates in RNA Polymerase III TranscriptionPathwayReactome R-HSA-74158Inferred only
GTF3C5 participates in RNA Polymerase III Transcription InitiationPathwayReactome R-HSA-76046Inferred only
GTF3C5 participates in RNA Polymerase III Transcription Initiation From Type 1 PromoterPathwayReactome R-HSA-76061Inferred only
GTF3C5 participates in RNA Polymerase III Transcription Initiation From Type 2 PromoterPathwayReactome R-HSA-76066Inferred only

Other names

7 names

Resolves to: GTF3C5

Also called: IIIC 63 kDa subunitIIIC subunit epsilonTF3C-epsilonTFIIIC 63 kDa subunitTFIIIC63Transcription factor IIIC 63 kDa subunitTranscription factor IIIC subunit epsilon

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