What it touches on the way
Mechanistic reach
17 entities
17 entities reached.
0 reported hops17 assembled from the scaffold
- GSTP1ProteinUNIPROT:P09211metabolized byInferred only44 paths44 endpoints
- GSTA1ProteinUNIPROT:P08263metabolized byInferred only27 paths27 endpoints
- GSTM4ProteinUNIPROT:Q03013metabolized byInferred only26 paths26 endpoints
- GSTA2ProteinUNIPROT:P09210metabolized byInferred only23 paths23 endpoints
- GSTO1ProteinUNIPROT:P78417metabolized byInferred only22 paths22 endpoints
- GSTM1ProteinUNIPROT:P09488metabolized byInferred only19 paths19 endpoints
- MGST1ProteinUNIPROT:P10620substrate ofInferred only15 paths15 endpoints
- GSTA3ProteinUNIPROT:Q16772metabolized byInferred only14 paths14 endpoints
- GSTM3ProteinUNIPROT:P21266metabolized byInferred only13 paths13 endpoints
- GSTM2ProteinUNIPROT:P28161metabolized byInferred only12 paths12 endpoints
- MGST3ProteinUNIPROT:O14880substrate ofInferred only11 paths11 endpoints
- MGST2ProteinUNIPROT:Q99735substrate ofInferred only10 paths10 endpoints
Show the remaining 5
- GSTA4ProteinUNIPROT:O15217metabolized byInferred only9 paths9 endpoints
- GSTM5ProteinUNIPROT:P46439metabolized byInferred only9 paths9 endpoints
- GSTA5ProteinUNIPROT:Q7RTV2metabolized byInferred only9 paths9 endpoints
- GSTO2ProteinUNIPROT:Q9H4Y5metabolized byInferred only9 paths9 endpoints
- GSTK1ProteinUNIPROT:Q9Y2Q3metabolized byInferred only7 paths7 endpoints
What the reference databases state
Statements
17 statements
17 statements · 1 reference database · Subject: trichloroethene · Sources: Human-GEM
- trichloroethene is metabolised by GSTA1ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is metabolised by GSTA2ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is metabolised by GSTA3ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is metabolised by GSTA4ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is metabolised by GSTA5ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is metabolised by GSTK1ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is metabolised by GSTM1ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is metabolised by GSTM2ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is metabolised by GSTM3ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is metabolised by GSTM4ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is metabolised by GSTM5ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is metabolised by GSTO1ProteinHuman-GEM MAR07029Inferred only
Show the remaining 5
- trichloroethene is metabolised by GSTO2ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is metabolised by GSTP1ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is a substrate of MGST1ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is a substrate of MGST2ProteinHuman-GEM MAR07029Inferred only
- trichloroethene is a substrate of MGST3ProteinHuman-GEM MAR07029Inferred only
Reactions
7 reactions
CHEBI:16856+trichloroethenechloride+MAM02850c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTM1 or GSTM5 or GSTM3 or MGST3 or GSTO1 or GSTM4 or GSTA4 or GSTA3 and 5 more alternatives
Reaction pageLeft to rightBalancedEC 2.5.1.18GO:0005829
Human-GEM MAR07029CC BY 4.0Reference data
proton+NADPH(4-)+dioxygen+trichloroethenewater+NADP(3-)+MAM02954c
Catalysed by CYP3A43 or CYP3A5 or CYP2C18 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP3A4 or CYP3A7 or CYP2C19
Reaction pageLeft to rightBalancedEC 1.14.14.1GO:0005829
Human-GEM MAR07030CC BY 4.0Reference data
proton+NADPH(4-)+dioxygen+trichloroetheneMAM01441c+water+NADP(3-)
Catalysed by CYP3A43 or CYP3A5 or CYP2C18 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP3A4 or CYP3A7 or CYP2C19
Reaction pageLeft to rightBalancedEC 1.14.14.1GO:0005829
Human-GEM MAR07033CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR07114CC BY 4.0Reference data
trichloroethenetrichloroethene
Reaction pageLeft to rightBalancedGO:0005615, GO:0005829
Human-GEM MAR07115CC BY 4.0Reference data
trichloroethene+chloride+A+hydronCHEBI:17300+AH2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:20353CC BY 4.0Reference data
trichloroethene+AH2CHEBI:28805+chloride+A+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:67992CC BY 4.0Reference data