Proteins/UNIPROT:O75326

SEMA7A

ProteinUNIPROT:O75326

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes..

Function from UniProtKB (O75326), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

cholestasis, progressive familial intrahepatic, 11 has a germline basis in SEMA7ADiseaseGenCC HGNC:10741|MONDO:0030815Inferred only

Statements

24 statements

24 statements · 4 reference databases · Subject: SEMA7A · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

SEMA7A covaries with FEM1BProteinHetionet hetionet:covaries:10116-8482Inferred only
GRK6 covaries with SEMA7AProteinHetionet hetionet:covaries:2870-8482Inferred only
HOXD3 covaries with SEMA7AProteinHetionet hetionet:covaries:3232-8482Inferred only
NR4A3 covaries with SEMA7AProteinHetionet hetionet:covaries:8013-8482Inferred only
SPEG covaries with SEMA7AProteinHetionet hetionet:covaries:10290-8482Inferred only
SEMA7A covaries with TEX30ProteinHetionet hetionet:covaries:8482-93081Inferred only
SEMA7A covaries with TSKUProteinHetionet hetionet:covaries:25987-8482Inferred only
ABL1 interacts with SEMA7AProteinHetionet hetionet:interacts:25-8482Inferred only
FYN interacts with SEMA7AProteinHetionet hetionet:interacts:2534-8482Inferred only
GRB2 interacts with SEMA7AProteinHetionet hetionet:interacts:2885-8482Inferred only
NCK1 interacts with SEMA7AProteinHetionet hetionet:interacts:4690-8482Inferred only
SEMA7A interacts with PLXNC1ProteinHetionet hetionet:interacts:10154-8482Inferred only

Show the remaining 12

SEMA7A participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
SEMA7A participates in Axon guidancePathwayWikiPathways WP5289Inferred only
SEMA7A participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
SEMA7A participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
SEMA7A participates in Other semaphorin interactionsPathwayReactome R-HSA-416700Inferred only
SEMA7A participates in Semaphorin interactionsPathwayReactome R-HSA-373755Inferred only
SEMA7A regulates positive regulation of axon extensionBiological processgene ontology O75326|GO:0045773Inferred only
SEMA7A regulates positive regulation of cell migrationBiological processgene ontology O75326|GO:0030335Inferred only
SEMA7A regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology O75326|GO:0070374Inferred only
SEMA7A regulates positive regulation of macrophage cytokine productionBiological processgene ontology O75326|GO:0060907Inferred only
SEMA7A regulates regulation of inflammatory responseBiological processgene ontology O75326|GO:0050727Inferred only
SEMA7A regulates regulation of synapse maturationBiological processgene ontology O75326|GO:0090128Inferred only

Other names

10 names

Resolves to: SEMA7A

Also called: CD antigen CD108CD108CDw108JMH blood group antigenJohn-Milton-Hargen human blood group AgSema K1Sema LSEMALSemaphorin-K1Semaphorin-L

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