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Proteins/UNIPROT:P25101

EDNRA

Protein·UNIPROT:P25101

Open in the graph

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

Function from UniProtKB (P25101), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

cystic fibrosis has a germline basis in EDNRADiseaseGenCC HGNC:3179|MONDO:0009061Inferred only
mandibulofacial dysostosis with alopecia has a germline basis in EDNRADiseaseGenCC HGNC:3179|MONDO:0014608Inferred only

Statements

26 statements

26 statements · 4 reference databases · Subject: EDNRA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

EDNRA interacts with COPS5ProteinHetionet hetionet:interacts:10987-1909Inferred only
EDN1 interacts with EDNRAProteinHetionet hetionet:interacts:1906-1909Inferred only
EDN3 interacts with EDNRAProteinHetionet hetionet:interacts:1908-1909Inferred only
EDNRA interacts with GNA11ProteinHetionet hetionet:interacts:1909-2767Inferred only
EDNRA interacts with GNAI2ProteinHetionet hetionet:interacts:1909-2771Inferred only
EDNRA interacts with GRK6ProteinHetionet hetionet:interacts:1909-2870Inferred only
EDNRA interacts with KAT5ProteinHetionet hetionet:interacts:10524-1909Inferred only
EDNRA participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
EDNRA participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
EDNRA participates in Endothelin pathwaysPathwayWikiPathways WP2197Inferred only
EDNRA participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
EDNRA participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only

Show the remaining 14

EDNRA participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
EDNRA participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
EDNRA participates in GPCRs otherPathwayWikiPathways WP117Inferred only
EDNRA participates in miR 509 3p alteration of YAP1 ECM axisPathwayWikiPathways WP3967Inferred only
EDNRA participates in Peptide GPCRsPathwayWikiPathways WP24Inferred only
EDNRA participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
EDNRA participates in Prostaglandin synthesis and regulationPathwayWikiPathways WP98Inferred only
EDNRA participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
EDNRA participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
EDNRA regulates positive regulation of cation channel activityBiological processgene ontology P25101|GO:2001259Inferred only
EDNRA regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology P25101|GO:0007204Inferred only
EDNRA regulates regulation of blood pressureBiological processgene ontology P25101|GO:0008217Inferred only
EDNRA regulates regulation of heart rateBiological processgene ontology P25101|GO:0002027Inferred only
EDNRA regulates regulation of protein localization to cell leading edgeBiological processgene ontology P25101|GO:1905871Inferred only

Other names

6 names

Resolves to: EDNRA

Also called: Endothelin receptor type AET-AETAETA-RETRAhET-AR

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