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Proteins/UNIPROT:P32298
Specifically phosphorylates the activated forms of G protein-coupled receptors, such as ADRB2, DRD1 and DRD3. Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization. Mediates phosphorylation of DRD1 in the absence of dopamine activation, resulting in constitutive desensitization..
[Isoform 1]: Phosphorylates rhodopsin and its activity is inhibited by calmodulin..
[Isoform 2]: In contrast to isoform 1, does not phosphorylate rhodopsin and does not interact with calmodulin..
[Isoform 3]: In contrast to isoform 1, does not phosphorylate rhodopsin and does not interact with calmodulin..
[Isoform 4]: In contrast to isoform 1, does not phosphorylate rhodopsin and does not interact with calmodulin..
Function from UniProtKB (P32298), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
27 statements
27 statements · 3 reference databases · Subject: GRK4 · Sources: gene ontology, Hetionet, WikiPathways
1 reaction
[G protein-coupled receptor]+ATP(4-)[G protein-coupled receptor]-phosphate+ADP(3-)+hydron
Catalysed by GRK2 or GRK4 or GRK5 or GRK3 or GRK6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12008CC BY 4.0Reference data
4 names
Resolves to: GRK4