Pathway
OADH complex synthesizes glutaryl-CoA from 2-OA
The mitochondrial alpha-oxoadipate dehydrogenase complex (OADH, OADHC) catalyzes the overall reaction of 2-oxoadipate (OA), CoASH, and NAD+ to form glutaryl-CoA, CO2, and NADH. The complex contains multiple copies of three different enzymes, E1 (DHTKD1), E2 (DLST), and E3 (DLD), each with distinct catalytic activities. As in other dehydrogenase complexes, the lipoyl scaffold bound to DLST accepts the glutaryl moiety after the decarboxylation of OA by DHTKD1. Secondly, glutaryl is transferred to CoA by DLST, and finally, the dihydrolipoyl moiety is dehydrogenated by DLD using NAD+. Crystallographic studies show that in the OADH complex, DHTKD1 dimers bind to a 24-mer DLST core.
What the reference databases state
Statements
3 statements
3 statements · 1 reference database · Subject: OADH complex synthesizes glutaryl-CoA from 2-OA · Sources: Reactome
- DHTKD1 participates in OADH complex synthesizes glutaryl-CoA from 2-OAProteinReactome R-HSA-9858328Inferred only
- DLD participates in OADH complex synthesizes glutaryl-CoA from 2-OAProteinReactome R-HSA-9858328Inferred only
- DLST participates in OADH complex synthesizes glutaryl-CoA from 2-OAProteinReactome R-HSA-9858328Inferred only